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Syneresis and delayed detachment in agar plates.
Divoux T, Mao B, Snabre P. Divoux T, et al. Among authors: mao b. Soft Matter. 2015 May 14;11(18):3677-85. doi: 10.1039/c5sm00433k. Soft Matter. 2015. PMID: 25812667
5,7-dihydroxy-3',4',5'-trimethoxyflavone mitigates lead induced neurotoxicity in rats via its chelating, antioxidant, anti-inflammatory and monoaminergic properties.
Singh V, Shri R, Sood P, Singh M, Singh TG, Singh R, Kumar A, Ahmad SF. Singh V, et al. Food Chem Toxicol. 2024 May 18:114747. doi: 10.1016/j.fct.2024.114747. Online ahead of print. Food Chem Toxicol. 2024. PMID: 38768937
Cognitive and motor functions were assessed using Morris Water Maze and horizontal bar tests. Lead, monoamine oxidase (MAO) A and B enzymes, reduced glutathione (GSH), thiobarbituric acid reactive species (TBARS), Tumor necrosis factor-alpha (TNF-alpha), and IL-6 le …
Cognitive and motor functions were assessed using Morris Water Maze and horizontal bar tests. Lead, monoamine oxidase (MAO) A …
Novel biaryloxazolidinone derivatives with broad-spectrum antibacterial activity, favorable drug-like profiles and in vivo efficacy against linezolid-resistant Staphylococcusaureus.
Duan M, Qiu C, Huang X, Sun L, He X, Wang Z, Yue H, Wang K, Qi Y, Peng S, Shi X, Xi Z, Tong M, Ding X, Hou Y, Zhao Y. Duan M, et al. Eur J Med Chem. 2024 May 17;273:116493. doi: 10.1016/j.ejmech.2024.116493. Online ahead of print. Eur J Med Chem. 2024. PMID: 38761790
Compound 8b was demonstrated as a promising candidate through druglikeness evaluation including metabolism in microsomes and plasma, Caco-2 cell permeability, plasma protein binding, cytotoxicity, and inhibition of CYP450 and human monoamine oxidase. Notably, compou …
Compound 8b was demonstrated as a promising candidate through druglikeness evaluation including metabolism in microsomes and plasma, Caco-2 …
Tonic excitation by astrocytic GABA causes neuropathic pain by augmenting neuronal activity and glucose metabolism.
Ju YH, Cho J, Park JY, Kim H, Hong EB, Lee CJ, Chung E, Kim HI, Nam MH. Ju YH, et al. Exp Mol Med. 2024 May 17. doi: 10.1038/s12276-024-01232-z. Online ahead of print. Exp Mol Med. 2024. PMID: 38760512 Free article.
Using multiple electrophysiological methods, we demonstrated that neuronal hyperexcitability is attributed to both increased astrocytic GABA synthesis via monoamine oxidase B (MAOB) and the depolarized reversal potential of GABA-mediated currents (E(GABA)) via the d …
Using multiple electrophysiological methods, we demonstrated that neuronal hyperexcitability is attributed to both increased astrocytic GABA …
Synthesis and Monoamine Oxidase Inhibitory Activity of Halogenated Flavones.
Castillo-Arellano JI, Stryker Z, Wyatt MD, León F. Castillo-Arellano JI, et al. ACS Med Chem Lett. 2024 Apr 3;15(5):610-618. doi: 10.1021/acsmedchemlett.3c00573. eCollection 2024 May 9. ACS Med Chem Lett. 2024. PMID: 38746894
Small molecule neurotransmitters containing amines are metabolized by monoamine oxidase (MAO) in the nervous system. Monoamine oxidase inhibitors are a valuable class of drugs prescribed for the management of neurological disorders, including depressio …
Small molecule neurotransmitters containing amines are metabolized by monoamine oxidase (MAO) in the nervous system. Monoam …
In vitro and in vivo metabolism of psilocybin's active metabolite psilocin.
Thomann J, Kolaczynska KE, Stoeckmann OV, Rudin D, Vizeli P, Hoener MC, Pryce CR, Vollenweider FX, Liechti ME, Duthaler U. Thomann J, et al. Front Pharmacol. 2024 Apr 29;15:1391689. doi: 10.3389/fphar.2024.1391689. eCollection 2024. Front Pharmacol. 2024. PMID: 38741590 Free PMC article.
Metabolism studies were performed using human liver microsomes (HLM), cytochrome P450 (CYP) enzymes, monoamine oxidase (MAO), and UDP-glucuronosyltransferase (UGT). In vivo, metabolism was examined using male C57BL/6J mice and human plasma samples. ...
Metabolism studies were performed using human liver microsomes (HLM), cytochrome P450 (CYP) enzymes, monoamine oxidase (MAO), …
26,993 results
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