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Aglycone sterics-selective enzymatic glycan remodeling.
Mao A, Zhang Y, Wang G, Zhong T, Chen X, Wang H, Xie R, Wang X, Ding L, Ju H. Mao A, et al. iScience. 2022 Jun 13;25(7):104578. doi: 10.1016/j.isci.2022.104578. eCollection 2022 Jul 15. iScience. 2022. PMID: 35789841 Free PMC article.
Synthesis and Monoamine Oxidase Inhibitory Activity of Halogenated Flavones.
Castillo-Arellano JI, Stryker Z, Wyatt MD, León F. Castillo-Arellano JI, et al. ACS Med Chem Lett. 2024 Apr 3;15(5):610-618. doi: 10.1021/acsmedchemlett.3c00573. eCollection 2024 May 9. ACS Med Chem Lett. 2024. PMID: 38746894
Small molecule neurotransmitters containing amines are metabolized by monoamine oxidase (MAO) in the nervous system. Monoamine oxidase inhibitors are a valuable class of drugs prescribed for the management of neurological disorders, including depressio …
Small molecule neurotransmitters containing amines are metabolized by monoamine oxidase (MAO) in the nervous system. Monoam …
In vitro and in vivo metabolism of psilocybin's active metabolite psilocin.
Thomann J, Kolaczynska KE, Stoeckmann OV, Rudin D, Vizeli P, Hoener MC, Pryce CR, Vollenweider FX, Liechti ME, Duthaler U. Thomann J, et al. Front Pharmacol. 2024 Apr 29;15:1391689. doi: 10.3389/fphar.2024.1391689. eCollection 2024. Front Pharmacol. 2024. PMID: 38741590 Free PMC article.
Metabolism studies were performed using human liver microsomes (HLM), cytochrome P450 (CYP) enzymes, monoamine oxidase (MAO), and UDP-glucuronosyltransferase (UGT). In vivo, metabolism was examined using male C57BL/6J mice and human plasma samples. ...However, the C …
Metabolism studies were performed using human liver microsomes (HLM), cytochrome P450 (CYP) enzymes, monoamine oxidase (MAO), …
Dihydroxanthene-based monoamine oxidase A-activated photosensitizers for photodynamic/photothermal therapy of tumors.
Mo Q, Zhong T, Cao B, Han Z, Hu X, Zhao S, Wei X, Yang Z, Qin J. Mo Q, et al. Eur J Med Chem. 2024 May 3;272:116474. doi: 10.1016/j.ejmech.2024.116474. Online ahead of print. Eur J Med Chem. 2024. PMID: 38735149
Small molecule photosensitizers for combined in vivo tailored cancer diagnostics and photodynamic/photothermal therapy are desperately needed. Monoamine oxidase A (MAO-A)-activated therapeutic and diagnostic compounds provide great selectivity because …
Small molecule photosensitizers for combined in vivo tailored cancer diagnostics and photodynamic/photothermal therapy are desperately neede …
Kinetic modeling of the monoamine oxidase-B radioligand [(18)F]SMBT-1 in human brain with positron emission tomography.
Lopresti BJ, Stehouwer J, Reese AC, Mason NS, Royse SK, Narendran R, Laymon CM, Lopez OL, Cohen AD, Mathis CA, Villemagne VL. Lopresti BJ, et al. J Cereb Blood Flow Metab. 2024 May 12:271678X241254679. doi: 10.1177/0271678X241254679. Online ahead of print. J Cereb Blood Flow Metab. 2024. PMID: 38735059
This paper describes pharmacokinetic analyses of the monoamine-oxidase-B (MAO-B) radiotracer [(18)F](S)-(2-methylpyrid-5-yl)-6-[(3-fluoro-2-hydroxy)propoxy]quinoline ([(18)F]SMBT-1) for positron emission tomography (PET) brain imaging. ...
This paper describes pharmacokinetic analyses of the monoamine-oxidase-B (MAO-B) radiotracer [(18)F](S)-(2-methylpyrid-5-yl)-6 …
Brain-targeted Tet-1 peptide-PLGA nanoparticles for berberine delivery against STZ-induced Alzheimer's disease in a rat model: Alleviation of hippocampal synaptic dysfunction, Tau pathology and amyloidogenesis.
Saleh SR, Abd-Elmegied A, Aly Madhy S, Khattab SN, Sheta E, Elnozahy FY, Mehanna RA, Ghareeb DA, Abd-Elmonem NM. Saleh SR, et al. Int J Pharm. 2024 May 9:124218. doi: 10.1016/j.ijpharm.2024.124218. Online ahead of print. Int J Pharm. 2024. PMID: 38734273
Cognitive improvement was assessed using the Morris Water Maze. Brain acetylcholinesterase and monoamine oxidase activities, amyloid beta42 (Abeta42), and brain glycemic markers were estimated. ...
Cognitive improvement was assessed using the Morris Water Maze. Brain acetylcholinesterase and monoamine oxidase activities, a …
26,196 results
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