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Hydrogen sulfide donor AP123 restores endothelial nitric oxide-dependent vascular function in hyperglycemia via a CREB-dependent pathway.
Montanaro R, Vellecco V, Torregrossa R, Casillo GM, Manzo OL, Mitidieri E, Bucci M, Castaldo S, Sorrentino R, Whiteman M, Smimmo M, Carriero F, Terrazzano G, Cirino G, d'Emmanuele di Villa Bianca R, Brancaleone V. Montanaro R, et al. Among authors: manzo ol. Redox Biol. 2023 Jun;62:102657. doi: 10.1016/j.redox.2023.102657. Epub 2023 Mar 4. Redox Biol. 2023. PMID: 36913800 Free PMC article.
Nogo-A reduces ceramide de novo biosynthesis to protect from heart failure.
Sasset L, Manzo OL, Zhang Y, Marino A, Rubinelli L, Riemma MA, Chalasani MLS, Dasoveanu DC, Roviezzo F, Jankauskas SS, Santulli G, Bucci MR, Lu TT, Di Lorenzo A. Sasset L, et al. Among authors: manzo ol. Cardiovasc Res. 2023 Mar 31;119(2):506-519. doi: 10.1093/cvr/cvac108. Cardiovasc Res. 2023. PMID: 35815623 Free PMC article.
Phosphodiesterases S-sulfhydration contributes to human skeletal muscle function.
Vellecco V, Panza E, Bibli SI, Casillo GM, Raucci F, Manzo OL, Smimmo M, Villani R, Cavezza MR, Fleming I, d'Emmanuele di Villa Bianca R, Maione F, Cirino G, Bucci M. Vellecco V, et al. Among authors: manzo ol. Pharmacol Res. 2022 Mar;177:106108. doi: 10.1016/j.phrs.2022.106108. Epub 2022 Feb 1. Pharmacol Res. 2022. PMID: 35121122
Duchenne's muscular dystrophy involves a defective transsulfuration pathway activity.
Panza E, Vellecco V, Iannotti FA, Paris D, Manzo OL, Smimmo M, Mitilini N, Boscaino A, de Dominicis G, Bucci M, Di Lorenzo A, Cirino G. Panza E, et al. Among authors: manzo ol. Redox Biol. 2021 Sep;45:102040. doi: 10.1016/j.redox.2021.102040. Epub 2021 Jun 19. Redox Biol. 2021. PMID: 34174560 Free PMC article.
Involvement of 3',5'-cyclic inosine monophosphate in cystathionine γ-lyase-dependent regulation of the vascular tone.
Mitidieri E, Vellecco V, Brancaleone V, Vanacore D, Manzo OL, Martin E, Sharina I, Krutsenko Y, Monti MC, Morretta E, Papapetropoulos A, Caliendo G, Frecentese F, Cirino G, Sorrentino R, d'Emmanuele di Villa Bianca R, Bucci M. Mitidieri E, et al. Among authors: manzo ol. Br J Pharmacol. 2021 Sep;178(18):3765-3782. doi: 10.1111/bph.15516. Epub 2021 Jun 11. Br J Pharmacol. 2021. PMID: 33931865 Free PMC article.
Anomalous Kv 7 channel activity in human malignant hyperthermia syndrome unmasks a key role for H2 S and persulfidation in skeletal muscle.
Vellecco V, Martelli A, Bibli IS, Vallifuoco M, Manzo OL, Panza E, Citi V, Calderone V, de Dominicis G, Cozzolino C, Basso EM, Mariniello M, Fleming I, Mancini A, Bucci M, Cirino G. Vellecco V, et al. Among authors: manzo ol. Br J Pharmacol. 2020 Feb;177(4):810-823. doi: 10.1111/bph.14700. Epub 2019 May 3. Br J Pharmacol. 2020. PMID: 31051045 Free PMC article.