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The Oncolytic Adenovirus XVir-N-31 Joins Forces with CDK4/6 Inhibition Augmenting Innate and Adaptive Antitumor Immunity in Ewing Sarcoma.
Schober SJ, Schoening C, Eck J, Middendorf C, Lutsch J, Knoch P, von Ofen AJ, Gassmann H, Thiede M, Hauer J, Kolk A, Mantwill K, Gschwend JE, Burdach SEG, Nawroth R, Thiel U, Holm PS. Schober SJ, et al. Among authors: mantwill k. Clin Cancer Res. 2023 May 15;29(10):1996-2011. doi: 10.1158/1078-0432.CCR-22-1961. Clin Cancer Res. 2023. PMID: 36892582
YB-1 relocates to the nucleus in adenovirus-infected cells and facilitates viral replication by inducing E2 gene expression through the E2 late promoter.
Holm PS, Bergmann S, Jurchott K, Lage H, Brand K, Ladhoff A, Mantwill K, Curiel DT, Dobbelstein M, Dietel M, Gansbacher B, Royer HD. Holm PS, et al. Among authors: mantwill k. J Biol Chem. 2002 Mar 22;277(12):10427-34. doi: 10.1074/jbc.M106955200. Epub 2002 Jan 11. J Biol Chem. 2002. PMID: 11788582 Free article.
Inhibition of the multidrug-resistant phenotype by targeting YB-1 with a conditionally oncolytic adenovirus: implications for combinatorial treatment regimen with chemotherapeutic agents.
Mantwill K, Köhler-Vargas N, Bernshausen A, Bieler A, Lage H, Kaszubiak A, Surowiak P, Dravits T, Treiber U, Hartung R, Gansbacher B, Holm PS. Mantwill K, et al. Cancer Res. 2006 Jul 15;66(14):7195-202. doi: 10.1158/0008-5472.CAN-05-2339. Cancer Res. 2006. PMID: 16849566
Adenovirus-based virotherapy enabled by cellular YB-1 expression in vitro and in vivo.
Rognoni E, Widmaier M, Haczek C, Mantwill K, Holzmüller R, Gansbacher B, Kolk A, Schuster T, Schmid RM, Saur D, Kaszubiak A, Lage H, Holm PS. Rognoni E, et al. Among authors: mantwill k. Cancer Gene Ther. 2009 Oct;16(10):753-63. doi: 10.1038/cgt.2009.20. Epub 2009 Apr 10. Cancer Gene Ther. 2009. PMID: 19363467
23 results