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Targeting the Retinoblastoma/E2F repressive complex by CDK4/6 inhibitors amplifies oncolytic potency of an oncolytic adenovirus.
Koch J, Schober SJ, Hindupur SV, Schöning C, Klein FG, Mantwill K, Ehrenfeld M, Schillinger U, Hohnecker T, Qi P, Steiger K, Aichler M, Gschwend JE, Nawroth R, Holm PS. Koch J, et al. Among authors: mantwill k. Nat Commun. 2022 Aug 10;13(1):4689. doi: 10.1038/s41467-022-32087-5. Nat Commun. 2022. PMID: 35948546 Free PMC article.
YB-1 relocates to the nucleus in adenovirus-infected cells and facilitates viral replication by inducing E2 gene expression through the E2 late promoter.
Holm PS, Bergmann S, Jurchott K, Lage H, Brand K, Ladhoff A, Mantwill K, Curiel DT, Dobbelstein M, Dietel M, Gansbacher B, Royer HD. Holm PS, et al. Among authors: mantwill k. J Biol Chem. 2002 Mar 22;277(12):10427-34. doi: 10.1074/jbc.M106955200. Epub 2002 Jan 11. J Biol Chem. 2002. PMID: 11788582 Free article.
Inhibition of the multidrug-resistant phenotype by targeting YB-1 with a conditionally oncolytic adenovirus: implications for combinatorial treatment regimen with chemotherapeutic agents.
Mantwill K, Köhler-Vargas N, Bernshausen A, Bieler A, Lage H, Kaszubiak A, Surowiak P, Dravits T, Treiber U, Hartung R, Gansbacher B, Holm PS. Mantwill K, et al. Cancer Res. 2006 Jul 15;66(14):7195-202. doi: 10.1158/0008-5472.CAN-05-2339. Cancer Res. 2006. PMID: 16849566
Adenovirus-based virotherapy enabled by cellular YB-1 expression in vitro and in vivo.
Rognoni E, Widmaier M, Haczek C, Mantwill K, Holzmüller R, Gansbacher B, Kolk A, Schuster T, Schmid RM, Saur D, Kaszubiak A, Lage H, Holm PS. Rognoni E, et al. Among authors: mantwill k. Cancer Gene Ther. 2009 Oct;16(10):753-63. doi: 10.1038/cgt.2009.20. Epub 2009 Apr 10. Cancer Gene Ther. 2009. PMID: 19363467
23 results