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Discovery, Structure-Activity Relationship, and Antiparkinsonian Effect of a Potent and Brain-Penetrant Chemical Series of Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4.
J Med Chem. 2017 Oct 26;60(20):8515-8537. doi: 10.1021/acs.jmedchem.7b00991. Epub 2017 Oct 12.
J Med Chem. 2017.
PMID: 28902994
Chemical methodology as a source of small-molecule checkpoint inhibitors and heat shock protein 70 (Hsp70) modulators.
Huryn DM, Brodsky JL, Brummond KM, Chambers PG, Eyer B, Ireland AW, Kawasumi M, Laporte MG, Lloyd K, Manteau B, Nghiem P, Quade B, Seguin SP, Wipf P.
Huryn DM, et al. Among authors: manteau b.
Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):6757-62. doi: 10.1073/pnas.1015251108. Epub 2011 Apr 18.
Proc Natl Acad Sci U S A. 2011.
PMID: 21502524
Free PMC article.
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Trifluoromethyl ethers--synthesis and properties of an unusual substituent.
Leroux FR, Manteau B, Vors JP, Pazenok S.
Leroux FR, et al. Among authors: manteau b.
Beilstein J Org Chem. 2008;4:13. doi: 10.3762/bjoc.4.13. Epub 2008 Apr 29.
Beilstein J Org Chem. 2008.
PMID: 18941485
Free PMC article.
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