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Different ways to regulate the PPARalpha stability.
Blanquart C, Mansouri R, Fruchart JC, Staels B, Glineur C. Blanquart C, et al. Biochem Biophys Res Commun. 2004 Jun 25;319(2):663-70. doi: 10.1016/j.bbrc.2004.05.035. Biochem Biophys Res Commun. 2004. PMID: 15178457
PPARalpha blocks glucocorticoid receptor alpha-mediated transactivation but cooperates with the activated glucocorticoid receptor alpha for transrepression on NF-kappaB.
Bougarne N, Paumelle R, Caron S, Hennuyer N, Mansouri R, Gervois P, Staels B, Haegeman G, De Bosscher K. Bougarne N, et al. Proc Natl Acad Sci U S A. 2009 May 5;106(18):7397-402. doi: 10.1073/pnas.0806742106. Epub 2009 Apr 17. Proc Natl Acad Sci U S A. 2009. PMID: 19376972 Free PMC article.
3-Carboxamido-5-aryl-isoxazoles as new CB2 agonists for the treatment of colitis.
Tourteau A, Andrzejak V, Body-Malapel M, Lemaire L, Lemoine A, Mansouri R, Djouina M, Renault N, El Bakali J, Desreumaux P, Muccioli GG, Lambert DM, Chavatte P, Rigo B, Leleu-Chavain N, Millet R. Tourteau A, et al. Bioorg Med Chem. 2013 Sep 1;21(17):5383-94. doi: 10.1016/j.bmc.2013.06.010. Epub 2013 Jun 15. Bioorg Med Chem. 2013. PMID: 23849204
4-Oxo-1,4-dihydropyridines as selective CB₂ cannabinoid receptor ligands. Part 2: discovery of new agonists endowed with protective effect against experimental colitis.
El Bakali J, Gilleron P, Body-Malapel M, Mansouri R, Muccioli GG, Djouina M, Barczyk A, Klupsch F, Andrzejak V, Lipka E, Furman C, Lambert DM, Chavatte P, Desreumaux P, Millet R. El Bakali J, et al. J Med Chem. 2012 Oct 25;55(20):8948-52. doi: 10.1021/jm3008568. Epub 2012 Oct 12. J Med Chem. 2012. PMID: 23017078