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The immune modulatory peptide FhHDM-1 secreted by the helminth Fasciola hepatica prevents NLRP3 inflammasome activation by inhibiting endolysosomal acidification in macrophages.
Alvarado R, To J, Lund ME, Pinar A, Mansell A, Robinson MW, O'Brien BA, Dalton JP, Donnelly S. Alvarado R, et al. Among authors: mansell a. FASEB J. 2017 Jan;31(1):85-95. doi: 10.1096/fj.201500093R. Epub 2016 Sep 28. FASEB J. 2017. PMID: 27682204
The NLRP3 inflammasome is a multimeric protein complex that controls the production of IL-1beta, a cytokine that influences the development of both innate and adaptive immune responses. ...-Alvarado, R., To, J., Lund, M. E., Pinar, A., Mansell, A …
The NLRP3 inflammasome is a multimeric protein complex that controls the production of IL-1beta, a cytokine that influences th …
157 results