Manoharan M - Search Results

1

From bench to bedside: Improving the clinical safety of GalNAc-siRNA conjugates using seed-pairing destabilization.

Schlegel MK, Janas MM, Jiang Y, Barry JD, Davis W, Agarwal S, Berman D, Brown CR, Castoreno A, LeBlanc S, Liebow A, Mayo T, Milstein S, Nguyen T, Shulga-Morskaya S, Hyde S, Schofield S, Szeto J, Woods LB, Yilmaz VO, Manoharan M, Egli M, Charissé K, Sepp-Lorenzino L, Haslett P, Fitzgerald K, Jadhav V, Maier MA. Schlegel MK, et al. Among authors: manoharan m. Nucleic Acids Res. 2022 Jul 8;50(12):6656-6670. doi: 10.1093/nar/gkac539. Nucleic Acids Res. 2022. PMID: 35736224 Free PMC article.

2

Synthesis of chimeric oligonucleotides containing phosphodiester, phosphorothioate, and phosphoramidate linkages.

Maier MA, Guzaev AP, Manoharan M. Maier MA, et al. Among authors: manoharan m. Org Lett. 2000 Jun 29;2(13):1819-22. doi: 10.1021/ol005842h. Org Lett. 2000. PMID: 10891166

3

Detection of alkali metal ions in DNA crystals using state-of-the-art X-ray diffraction experiments.

Tereshko V, Wilds CJ, Minasov G, Prakash TP, Maier MA, Howard A, Wawrzak Z, Manoharan M, Egli M. Tereshko V, et al. Among authors: manoharan m. Nucleic Acids Res. 2001 Mar 1;29(5):1208-15. doi: 10.1093/nar/29.5.1208. Nucleic Acids Res. 2001. PMID: 11222771 Free PMC article.

4

Nuclear antisense effects of neutral, anionic and cationic oligonucleotide analogs.

Sazani P, Kang SH, Maier MA, Wei C, Dillman J, Summerton J, Manoharan M, Kole R. Sazani P, et al. Among authors: manoharan m. Nucleic Acids Res. 2001 Oct 1;29(19):3965-74. doi: 10.1093/nar/29.19.3965. Nucleic Acids Res. 2001. PMID: 11574678 Free PMC article.

5

High-affinity peptide nucleic acid oligomers containing tricyclic cytosine analogues.

Rajeev KG, Maier MA, Lesnik EA, Manoharan M. Rajeev KG, et al. Among authors: manoharan m. Org Lett. 2002 Dec 12;4(25):4395-8. doi: 10.1021/ol027026a. Org Lett. 2002. PMID: 12465896

6

Direct observation of a cytosine analogue that forms five hydrogen bonds to guanosine: guanidino G-clamp.

Wilds CJ, Maier MA, Tereshko V, Manoharan M, Egli M. Wilds CJ, et al. Among authors: manoharan m. Angew Chem Int Ed Engl. 2002 Jan 4;41(1):115-7. doi: 10.1002/1521-3773(20020104)41:1<115::aid-anie115>3.0.co;2-r. Angew Chem Int Ed Engl. 2002. PMID: 12491456 No abstract available.

7

Synthesis and characterization of oligonucleotides containing conformationally constrained bicyclo[3.1.0]hexane pseudosugar analogs.

Maier MA, Choi Y, Gaus H, Barchi JJ Jr, Marquez VE, Manoharan M. Maier MA, et al. Among authors: manoharan m. Nucleic Acids Res. 2004 Jul 9;32(12):3642-50. doi: 10.1093/nar/gkh667. Print 2004. Nucleic Acids Res. 2004. PMID: 15247346 Free PMC article.

8

Structural rationalization of a large difference in RNA affinity despite a small difference in chemistry between two 2'-O-modified nucleic acid analogues.

Pattanayek R, Sethaphong L, Pan C, Prhavc M, Prakash TP, Manoharan M, Egli M. Pattanayek R, et al. Among authors: manoharan m. J Am Chem Soc. 2004 Nov 24;126(46):15006-7. doi: 10.1021/ja044637k. J Am Chem Soc. 2004. PMID: 15547979

9

Stabilizing contributions of sulfur-modified nucleotides: crystal structure of a DNA duplex with 2'-O-[2-(methoxy)ethyl]-2-thiothymidines.

Diop-Frimpong B, Prakash TP, Rajeev KG, Manoharan M, Egli M. Diop-Frimpong B, et al. Among authors: manoharan m. Nucleic Acids Res. 2005 Sep 16;33(16):5297-307. doi: 10.1093/nar/gki823. Print 2005. Nucleic Acids Res. 2005. PMID: 16170156 Free PMC article.

10

2'-Fluoroarabino- and arabinonucleic acid show different conformations, resulting in deviating RNA affinities and processing of their heteroduplexes with RNA by RNase H.

Li F, Sarkhel S, Wilds CJ, Wawrzak Z, Prakash TP, Manoharan M, Egli M. Li F, et al. Among authors: manoharan m. Biochemistry. 2006 Apr 4;45(13):4141-52. doi: 10.1021/bi052322r. Biochemistry. 2006. PMID: 16566588 Free PMC article.

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