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3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine.
Clement CC, D'Alessandro A, Thangaswamy S, Chalmers S, Furtado R, Spada S, Mondanelli G, Ianni F, Gehrke S, Gargaro M, Manni G, Cara LCL, Runge P, Tsai WL, Karaman S, Arasa J, Fernandez-Rodriguez R, Beck A, Macchiarulo A, Gadina M, Halin C, Fallarino F, Skobe M, Veldhoen M, Moretti S, Formenti S, Demaria S, Soni RK, Galarini R, Sardella R, Lauvau G, Putterman C, Alitalo K, Grohmann U, Santambrogio L. Clement CC, et al. Among authors: manni g. Nat Commun. 2021 Jul 21;12(1):4447. doi: 10.1038/s41467-021-24785-3. Nat Commun. 2021. PMID: 34290243 Free PMC article.
S1P promotes migration, differentiation and immune regulatory activity in amniotic-fluid-derived stem cells.
Romani R, Manni G, Donati C, Pirisinu I, Bernacchioni C, Gargaro M, Pirro M, Calvitti M, Bagaglia F, Sahebkar A, Clerici G, Matino D, Pomili G, Di Renzo GC, Talesa VN, Puccetti P, Fallarino F. Romani R, et al. Among authors: manni g. Eur J Pharmacol. 2018 Aug 15;833:173-182. doi: 10.1016/j.ejphar.2018.06.005. Epub 2018 Jun 7. Eur J Pharmacol. 2018. PMID: 29886240 Free PMC article.
Engagement of Nuclear Coactivator 7 by 3-Hydroxyanthranilic Acid Enhances Activation of Aryl Hydrocarbon Receptor in Immunoregulatory Dendritic Cells.
Gargaro M, Vacca C, Massari S, Scalisi G, Manni G, Mondanelli G, Mazza EMC, Bicciato S, Pallotta MT, Orabona C, Belladonna ML, Volpi C, Bianchi R, Matino D, Iacono A, Panfili E, Proietti E, Iamandii IM, Cecchetti V, Puccetti P, Tabarrini O, Fallarino F, Grohmann U. Gargaro M, et al. Among authors: manni g. Front Immunol. 2019 Aug 20;10:1973. doi: 10.3389/fimmu.2019.01973. eCollection 2019. Front Immunol. 2019. PMID: 31481962 Free PMC article.
Positive allosteric modulation of indoleamine 2,3-dioxygenase 1 restrains neuroinflammation.
Mondanelli G, Coletti A, Greco FA, Pallotta MT, Orabona C, Iacono A, Belladonna ML, Albini E, Panfili E, Fallarino F, Gargaro M, Manni G, Matino D, Carvalho A, Cunha C, Maciel P, Di Filippo M, Gaetani L, Bianchi R, Vacca C, Iamandii IM, Proietti E, Boscia F, Annunziato L, Peppelenbosch M, Puccetti P, Calabresi P, Macchiarulo A, Santambrogio L, Volpi C, Grohmann U. Mondanelli G, et al. Among authors: manni g. Proc Natl Acad Sci U S A. 2020 Feb 18;117(7):3848-3857. doi: 10.1073/pnas.1918215117. Epub 2020 Feb 5. Proc Natl Acad Sci U S A. 2020. PMID: 32024760 Free PMC article.
Anakinra restores cellular proteostasis by coupling mitochondrial redox balance to autophagy.
van de Veerdonk FL, Renga G, Pariano M, Bellet MM, Servillo G, Fallarino F, De Luca A, Iannitti RG, Piobbico D, Gargaro M, Manni G, D'Onofrio F, Stincardini C, Sforna L, Borghi M, Castelli M, Pieroni S, Oikonomou V, Villella VR, Puccetti M, Giovagnoli S, Galarini R, Barola C, Maiuri L, Della Fazia MA, Cellini B, Talesa VN, Dinarello CA, Costantini C, Romani L. van de Veerdonk FL, et al. Among authors: manni g. J Clin Invest. 2022 Jan 18;132(2):e144983. doi: 10.1172/JCI144983. J Clin Invest. 2022. PMID: 34847078 Free PMC article.
Indoleamine 2,3-dioxygenase 1 activation in mature cDC1 promotes tolerogenic education of inflammatory cDC2 via metabolic communication.
Gargaro M, Scalisi G, Manni G, Briseño CG, Bagadia P, Durai V, Theisen DJ, Kim S, Castelli M, Xu CA, Meyer Zu Hörste G, Servillo G, Della Fazia MA, Mencarelli G, Ricciuti D, Padiglioni E, Giacchè N, Colliva C, Pellicciari R, Calvitti M, Zelante T, Fuchs D, Orabona C, Boon L, Bessede A, Colonna M, Puccetti P, Murphy TL, Murphy KM, Fallarino F. Gargaro M, et al. Among authors: manni g. Immunity. 2022 Jun 14;55(6):1032-1050.e14. doi: 10.1016/j.immuni.2022.05.013. Immunity. 2022. PMID: 35704993 Free PMC article.
133 results