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Safe and effective treatments are needed for cryptosporidiosis, a truly neglected tropical disease.
Gilbert IH, Vinayak S, Striepen B, Manjunatha UH, Khalil IA, Van Voorhis WC; Cryptosporidiosis Therapeutics Advocacy Group CTAG; Cryptosporidiosis Therapeutics Advocacy CTAG. Gilbert IH, et al. Among authors: manjunatha uh. BMJ Glob Health. 2023 Aug;8(8):e012540. doi: 10.1136/bmjgh-2023-012540. BMJ Glob Health. 2023. PMID: 37541693 Free PMC article. No abstract available.
Cyanotriazoles are selective topoisomerase II poisons that rapidly cure trypanosome infections.
Rao SPS, Gould MK, Noeske J, Saldivia M, Jumani RS, Ng PS, René O, Chen YL, Kaiser M, Ritchie R, Francisco AF, Johnson N, Patra D, Cheung H, Deniston C, Schenk AD, Cortopassi WA, Schmidt RS, Wiedemar N, Thomas B, Palkar R, Ghafar NA, Manoharan V, Luu C, Gable JE, Wan KF, Myburgh E, Mottram JC, Barnes W, Walker J, Wartchow C, Aziz N, Osborne C, Wagner J, Sarko C, Kelly JM, Manjunatha UH, Mäser P, Jiricek J, Lakshminarayana SB, Barrett MP, Diagana TT. Rao SPS, et al. Among authors: manjunatha uh. Science. 2023 Jun 30;380(6652):1349-1356. doi: 10.1126/science.adh0614. Epub 2023 Jun 29. Science. 2023. PMID: 37384702 Free article.
Benzoheterocyclic Oxime Carbamates Active against Mycobacterium tuberculosis: Synthesis, Structure-Activity Relationship, Metabolism, and Biology Triaging.
van der Westhuyzen R, Mabhula A, Njaria PM, Müller R, Ngumbu Muhunga D, Taylor D, Lawrence N, Njoroge M, Brunschwig C, Moosa A, Singh V, Rao SPS, Manjunatha UH, Smith PW, Warner DF, Street LJ, Chibale K. van der Westhuyzen R, et al. Among authors: manjunatha uh. J Med Chem. 2021 Jul 8;64(13):9444-9457. doi: 10.1021/acs.jmedchem.1c00707. Epub 2021 Jun 17. J Med Chem. 2021. PMID: 34138573
Opportunities and Challenges in Developing a Cryptosporidium Controlled Human Infection Model for Testing Antiparasitic Agents.
Jumani RS, Blais J, Tillmann HC, Segal F, Wetty D, Ostermeier C, Nuber N, Lakshman J, Aziz N, Chandra R, Chen WH, Chappell CL, Diagana TT, Manjunatha UH. Jumani RS, et al. Among authors: manjunatha uh. ACS Infect Dis. 2021 May 14;7(5):959-968. doi: 10.1021/acsinfecdis.1c00057. Epub 2021 Apr 6. ACS Infect Dis. 2021. PMID: 33822577 Free PMC article.
Use-case scenarios for an anti-Cryptosporidium therapeutic.
Ashigbie PG, Shepherd S, Steiner KL, Amadi B, Aziz N, Manjunatha UH, Spector JM, Diagana TT, Kelly P. Ashigbie PG, et al. Among authors: manjunatha uh. PLoS Negl Trop Dis. 2021 Mar 11;15(3):e0009057. doi: 10.1371/journal.pntd.0009057. eCollection 2021 Mar. PLoS Negl Trop Dis. 2021. PMID: 33705395 Free PMC article. Review.
Setting Our Sights on Infectious Diseases.
De Rycker M, Horn D, Aldridge B, Amewu RK, Barry CE 3rd, Buckner FS, Cook S, Ferguson MAJ, Gobeau N, Herrmann J, Herrling P, Hope W, Keiser J, Lafuente-Monasterio MJ, Leeson PD, Leroy D, Manjunatha UH, McCarthy J, Miles TJ, Mizrahi V, Moshynets O, Niles J, Overington JP, Pottage J, Rao SPS, Read KD, Ribeiro I, Silver LL, Southern J, Spangenberg T, Sundar S, Taylor C, Van Voorhis W, White NJ, Wyllie S, Wyatt PG, Gilbert IH. De Rycker M, et al. Among authors: manjunatha uh. ACS Infect Dis. 2020 Jan 10;6(1):3-13. doi: 10.1021/acsinfecdis.9b00371. Epub 2019 Dec 6. ACS Infect Dis. 2020. PMID: 31808676 Free PMC article.
Innovations in Addressing Pediatric Diarrhea in Low Resource Settings.
Jumani RS, Spector JM, Izadnegahdar R, Kelly P, Diagana TT, Manjunatha UH. Jumani RS, et al. Among authors: manjunatha uh. ACS Infect Dis. 2020 Jan 10;6(1):14-24. doi: 10.1021/acsinfecdis.9b00315. Epub 2019 Oct 29. ACS Infect Dis. 2020. PMID: 31612701
A Cryptosporidium PI(4)K inhibitor is a drug candidate for cryptosporidiosis.
Manjunatha UH, Vinayak S, Zambriski JA, Chao AT, Sy T, Noble CG, Bonamy GMC, Kondreddi RR, Zou B, Gedeck P, Brooks CF, Herbert GT, Sateriale A, Tandel J, Noh S, Lakshminarayana SB, Lim SH, Goodman LB, Bodenreider C, Feng G, Zhang L, Blasco F, Wagner J, Leong FJ, Striepen B, Diagana TT. Manjunatha UH, et al. Nature. 2017 Jun 15;546(7658):376-380. doi: 10.1038/nature22337. Epub 2017 May 31. Nature. 2017. PMID: 28562588 Free PMC article.
38 results