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SARM1 is a metabolic sensor activated by an increased NMN/NAD+ ratio to trigger axon degeneration.
Figley MD, Gu W, Nanson JD, Shi Y, Sasaki Y, Cunnea K, Malde AK, Jia X, Luo Z, Saikot FK, Mosaiab T, Masic V, Holt S, Hartley-Tassell L, McGuinness HY, Manik MK, Bosanac T, Landsberg MJ, Kerry PS, Mobli M, Hughes RO, Milbrandt J, Kobe B, DiAntonio A, Ve T. Figley MD, et al. Among authors: manik mk. Neuron. 2021 Apr 7;109(7):1118-1136.e11. doi: 10.1016/j.neuron.2021.02.009. Epub 2021 Mar 2. Neuron. 2021. PMID: 33657413 Free PMC article.
NAD+ cleavage activity by animal and plant TIR domains in cell death pathways.
Horsefield S, Burdett H, Zhang X, Manik MK, Shi Y, Chen J, Qi T, Gilley J, Lai JS, Rank MX, Casey LW, Gu W, Ericsson DJ, Foley G, Hughes RO, Bosanac T, von Itzstein M, Rathjen JP, Nanson JD, Boden M, Dry IB, Williams SJ, Staskawicz BJ, Coleman MP, Ve T, Dodds PN, Kobe B. Horsefield S, et al. Among authors: manik mk. Science. 2019 Aug 23;365(6455):793-799. doi: 10.1126/science.aax1911. Science. 2019. PMID: 31439792
Structural Evolution of TIR-Domain Signalosomes.
Nimma S, Gu W, Maruta N, Li Y, Pan M, Saikot FK, Lim BYJ, McGuinness HY, Zaoti ZF, Li S, Desa S, Manik MK, Nanson JD, Kobe B. Nimma S, et al. Among authors: manik mk. Front Immunol. 2021 Nov 17;12:784484. doi: 10.3389/fimmu.2021.784484. eCollection 2021. Front Immunol. 2021. PMID: 34868065 Free PMC article. Review.
Cyclic ADP ribose isomers: Production, chemical structures, and immune signaling.
Manik MK, Shi Y, Li S, Zaydman MA, Damaraju N, Eastman S, Smith TG, Gu W, Masic V, Mosaiab T, Weagley JS, Hancock SJ, Vasquez E, Hartley-Tassell L, Kargios N, Maruta N, Lim BYJ, Burdett H, Landsberg MJ, Schembri MA, Prokes I, Song L, Grant M, DiAntonio A, Nanson JD, Guo M, Milbrandt J, Ve T, Kobe B. Manik MK, et al. Science. 2022 Sep 30;377(6614):eadc8969. doi: 10.1126/science.adc8969. Epub 2022 Sep 30. Science. 2022. PMID: 36048923
Plant and prokaryotic TIR domains generate distinct cyclic ADPR NADase products.
Bayless AM, Chen S, Ogden SC, Xu X, Sidda JD, Manik MK, Li S, Kobe B, Ve T, Song L, Grant M, Wan L, Nishimura MT. Bayless AM, et al. Among authors: manik mk. Sci Adv. 2023 Mar 15;9(11):eade8487. doi: 10.1126/sciadv.ade8487. Epub 2023 Mar 17. Sci Adv. 2023. PMID: 36930706 Free PMC article.
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