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Page 1
In vitro and in vivo evaluation of cysteine and site specific conjugated herceptin antibody-drug conjugates.
Jackson D, Atkinson J, Guevara CI, Zhang C, Kery V, Moon SJ, Virata C, Yang P, Lowe C, Pinkstaff J, Cho H, Knudsen N, Manibusan A, Tian F, Sun Y, Lu Y, Sellers A, Jia XC, Joseph I, Anand B, Morrison K, Pereira DS, Stover D. Jackson D, et al. Among authors: manibusan a. PLoS One. 2014 Jan 14;9(1):e83865. doi: 10.1371/journal.pone.0083865. eCollection 2014. PLoS One. 2014. PMID: 24454709 Free PMC article.
A general approach to site-specific antibody drug conjugates.
Tian F, Lu Y, Manibusan A, Sellers A, Tran H, Sun Y, Phuong T, Barnett R, Hehli B, Song F, DeGuzman MJ, Ensari S, Pinkstaff JK, Sullivan LM, Biroc SL, Cho H, Schultz PG, DiJoseph J, Dougher M, Ma D, Dushin R, Leal M, Tchistiakova L, Feyfant E, Gerber HP, Sapra P. Tian F, et al. Among authors: manibusan a. Proc Natl Acad Sci U S A. 2014 Feb 4;111(5):1766-71. doi: 10.1073/pnas.1321237111. Epub 2014 Jan 17. Proc Natl Acad Sci U S A. 2014. PMID: 24443552 Free PMC article.
A CXCR4-targeted site-specific antibody-drug conjugate.
Kularatne SA, Deshmukh V, Ma J, Tardif V, Lim RK, Pugh HM, Sun Y, Manibusan A, Sellers AJ, Barnett RS, Srinagesh S, Forsyth JS, Hassenpflug W, Tian F, Javahishvili T, Felding-Habermann B, Lawson BR, Kazane SA, Schultz PG. Kularatne SA, et al. Among authors: manibusan a. Angew Chem Int Ed Engl. 2014 Oct 27;53(44):11863-7. doi: 10.1002/anie.201408103. Epub 2014 Sep 11. Angew Chem Int Ed Engl. 2014. PMID: 25213874 Free PMC article.
Discovery of Pyrophosphate Diesters as Tunable, Soluble, and Bioorthogonal Linkers for Site-Specific Antibody-Drug Conjugates.
Kern JC, Cancilla M, Dooney D, Kwasnjuk K, Zhang R, Beaumont M, Figueroa I, Hsieh S, Liang L, Tomazela D, Zhang J, Brandish PE, Palmieri A, Stivers P, Cheng M, Feng G, Geda P, Shah S, Beck A, Bresson D, Firdos J, Gately D, Knudsen N, Manibusan A, Schultz PG, Sun Y, Garbaccio RM. Kern JC, et al. Among authors: manibusan a. J Am Chem Soc. 2016 Feb 3;138(4):1430-45. doi: 10.1021/jacs.5b12547. Epub 2016 Jan 25. J Am Chem Soc. 2016. PMID: 26745435
Recruiting cytotoxic T cells to folate-receptor-positive cancer cells.
Kularatne SA, Deshmukh V, Gymnopoulos M, Biroc SL, Xia J, Srinagesh S, Sun Y, Zou N, Shimazu M, Pinkstaff J, Ensari S, Knudsen N, Manibusan A, Axup J, Kim C, Smider V, Javahishvili T, Schultz PG. Kularatne SA, et al. Among authors: manibusan a. Angew Chem Int Ed Engl. 2013 Nov 11;52(46):12101-12104. doi: 10.1002/anie.201306866. Epub 2013 Sep 25. Angew Chem Int Ed Engl. 2013. PMID: 24573789 Free PMC article.
Development of Anti-CD74 Antibody-Drug Conjugates to Target Glucocorticoids to Immune Cells.
Brandish PE, Palmieri A, Antonenko S, Beaumont M, Benso L, Cancilla M, Cheng M, Fayadat-Dilman L, Feng G, Figueroa I, Firdos J, Garbaccio R, Garvin-Queen L, Gately D, Geda P, Haines C, Hseih S, Hodges D, Kern J, Knudsen N, Kwasnjuk K, Liang L, Ma H, Manibusan A, Miller PL, Moy LY, Qu Y, Shah S, Shin JS, Stivers P, Sun Y, Tomazela D, Woo HC, Zaller D, Zhang S, Zhang Y, Zielstorff M. Brandish PE, et al. Among authors: manibusan a. Bioconjug Chem. 2018 Jul 18;29(7):2357-2369. doi: 10.1021/acs.bioconjchem.8b00312. Epub 2018 Jul 2. Bioconjug Chem. 2018. PMID: 29923706
FGF21 analogs of sustained action enabled by orthogonal biosynthesis demonstrate enhanced antidiabetic pharmacology in rodents.
Mu J, Pinkstaff J, Li Z, Skidmore L, Li N, Myler H, Dallas-Yang Q, Putnam AM, Yao J, Bussell S, Wu M, Norman TC, Rodriguez CG, Kimmel B, Metzger JM, Manibusan A, Lee D, Zaller DM, Zhang BB, DiMarchi RD, Berger JP, Axelrod DW. Mu J, et al. Among authors: manibusan a. Diabetes. 2012 Feb;61(2):505-12. doi: 10.2337/db11-0838. Epub 2011 Dec 30. Diabetes. 2012. PMID: 22210323 Free PMC article.
Role of tRNA orthogonality in an expanded genetic code.
Javahishvili T, Manibusan A, Srinagesh S, Lee D, Ensari S, Shimazu M, Schultz PG. Javahishvili T, et al. Among authors: manibusan a. ACS Chem Biol. 2014 Apr 18;9(4):874-9. doi: 10.1021/cb4005172. Epub 2014 Jan 23. ACS Chem Biol. 2014. PMID: 24443971 Free PMC article.
12 results