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Garcinoic acid prevents β-amyloid (Aβ) deposition in the mouse brain.
Marinelli R, Torquato P, Bartolini D, Mas-Bargues C, Bellezza G, Gioiello A, Borras C, De Luca A, Fallarino F, Sebastiani B, Mani S, Sidoni A, Viña J, Leri M, Bucciantini M, Nardiello P, Casamenti F, Galli F. Marinelli R, et al. Among authors: mani s. J Biol Chem. 2020 Aug 14;295(33):11866-11876. doi: 10.1074/jbc.RA120.013303. Epub 2020 Jul 2. J Biol Chem. 2020. PMID: 32616652 Free PMC article.
Garcinoic Acid Is a Natural and Selective Agonist of Pregnane X Receptor.
Bartolini D, De Franco F, Torquato P, Marinelli R, Cerra B, Ronchetti R, Schon A, Fallarino F, De Luca A, Bellezza G, Ferri I, Sidoni A, Walton WG, Pellock SJ, Redinbo MR, Mani S, Pellicciari R, Gioiello A, Galli F. Bartolini D, et al. Among authors: mani s. J Med Chem. 2020 Apr 9;63(7):3701-3712. doi: 10.1021/acs.jmedchem.0c00012. Epub 2020 Mar 20. J Med Chem. 2020. PMID: 32160459 Free PMC article.
Deciphering structural bases of intestinal and hepatic selectivity in targeting pregnane X receptor with indole-based microbial mimics.
Li H, Illés P, Karunaratne CV, Nordstrøm LU, Luo X, Yang A, Qiu Y, Kurland IJ, Lukin DJ, Chen W, Jiskrová E, Krasulová K, Pečinková P, DesMarais VM, Liu Q, Albanese JM, Akki A, Longo M, Coffin B, Dou W, Mani S, Dvořák Z. Li H, et al. Among authors: mani s. Bioorg Chem. 2021 Apr;109:104661. doi: 10.1016/j.bioorg.2021.104661. Epub 2021 Jan 22. Bioorg Chem. 2021. PMID: 33636438 Free PMC article.
Targeting the Aryl Hydrocarbon Receptor with Microbial Metabolite Mimics Alleviates Experimental Colitis in Mice.
Grycová A, Joo H, Maier V, Illés P, Vyhlídalová B, Poulíková K, Sládeková L, Nádvorník P, Vrzal R, Zemánková L, Pečinková P, Poruba M, Zapletalová I, Večeřa R, Anzenbacher P, Ehrmann J, Ondra P, Jung JW, Mani S, Dvořák Z. Grycová A, et al. Among authors: mani s. J Med Chem. 2022 May 12;65(9):6859-6868. doi: 10.1021/acs.jmedchem.2c00208. Epub 2022 Apr 13. J Med Chem. 2022. PMID: 35416668
The pregnane X receptor and its microbiota-derived ligand indole 3-propionic acid regulate endothelium-dependent vasodilation.
Pulakazhi Venu VK, Saifeddine M, Mihara K, Tsai YC, Nieves K, Alston L, Mani S, McCoy KD, Hollenberg MD, Hirota SA. Pulakazhi Venu VK, et al. Among authors: mani s. Am J Physiol Endocrinol Metab. 2019 Aug 1;317(2):E350-E361. doi: 10.1152/ajpendo.00572.2018. Epub 2019 Jun 18. Am J Physiol Endocrinol Metab. 2019. PMID: 31211619 Free PMC article.
1,119 results