Mani S - Search Results

1

Garcinoic Acid Is a Natural and Selective Agonist of Pregnane X Receptor.

Bartolini D, De Franco F, Torquato P, Marinelli R, Cerra B, Ronchetti R, Schon A, Fallarino F, De Luca A, Bellezza G, Ferri I, Sidoni A, Walton WG, Pellock SJ, Redinbo MR, Mani S, Pellicciari R, Gioiello A, Galli F. Bartolini D, et al. Among authors: mani s. J Med Chem. 2020 Apr 9;63(7):3701-3712. doi: 10.1021/acs.jmedchem.0c00012. Epub 2020 Mar 20. J Med Chem. 2020. PMID: 32160459 Free PMC article.

2

Inhibition of drug metabolism by blocking the activation of nuclear receptors by ketoconazole.

Huang H, Wang H, Sinz M, Zoeckler M, Staudinger J, Redinbo MR, Teotico DG, Locker J, Kalpana GV, Mani S. Huang H, et al. Among authors: mani s. Oncogene. 2007 Jan 11;26(2):258-68. doi: 10.1038/sj.onc.1209788. Epub 2006 Jul 3. Oncogene. 2007. PMID: 16819505

3

Activated pregnenolone X-receptor is a target for ketoconazole and its analogs.

Wang H, Huang H, Li H, Teotico DG, Sinz M, Baker SD, Staudinger J, Kalpana G, Redinbo MR, Mani S. Wang H, et al. Among authors: mani s. Clin Cancer Res. 2007 Apr 15;13(8):2488-95. doi: 10.1158/1078-0432.CCR-06-1592. Clin Cancer Res. 2007. PMID: 17438109

4

The phytoestrogen coumestrol is a naturally occurring antagonist of the human pregnane X receptor.

Wang H, Li H, Moore LB, Johnson MD, Maglich JM, Goodwin B, Ittoop OR, Wisely B, Creech K, Parks DJ, Collins JL, Willson TM, Kalpana GV, Venkatesh M, Xie W, Cho SY, Roboz J, Redinbo M, Moore JT, Mani S. Wang H, et al. Among authors: mani s. Mol Endocrinol. 2008 Apr;22(4):838-57. doi: 10.1210/me.2007-0218. Epub 2007 Dec 20. Mol Endocrinol. 2008. PMID: 18096694 Free PMC article.

5

Synthesis of novel ketoconazole derivatives as inhibitors of the human Pregnane X Receptor (PXR; NR1I2; also termed SXR, PAR).

Das BC, Madhukumar AV, Anguiano J, Kim S, Sinz M, Zvyaga TA, Power EC, Ganellin CR, Mani S. Das BC, et al. Among authors: mani s. Bioorg Med Chem Lett. 2008 Jul 15;18(14):3974-7. doi: 10.1016/j.bmcl.2008.06.018. Epub 2008 Jun 10. Bioorg Med Chem Lett. 2008. PMID: 18583127

6

Elucidating the 'Jekyll and Hyde' nature of PXR: the case for discovering antagonists or allosteric antagonists.

Biswas A, Mani S, Redinbo MR, Krasowski MD, Li H, Ekins S. Biswas A, et al. Among authors: mani s. Pharm Res. 2009 Aug;26(8):1807-15. doi: 10.1007/s11095-009-9901-7. Epub 2009 May 5. Pharm Res. 2009. PMID: 19415465 Free PMC article. Review.

7

Alleviating cancer drug toxicity by inhibiting a bacterial enzyme.

Wallace BD, Wang H, Lane KT, Scott JE, Orans J, Koo JS, Venkatesh M, Jobin C, Yeh LA, Mani S, Redinbo MR. Wallace BD, et al. Among authors: mani s. Science. 2010 Nov 5;330(6005):831-5. doi: 10.1126/science.1191175. Science. 2010. PMID: 21051639 Free PMC article.

8

Acetylation of pregnane X receptor protein determines selective function independent of ligand activation.

Biswas A, Pasquel D, Tyagi RK, Mani S. Biswas A, et al. Among authors: mani s. Biochem Biophys Res Commun. 2011 Mar 18;406(3):371-6. doi: 10.1016/j.bbrc.2011.02.048. Epub 2011 Feb 15. Biochem Biophys Res Commun. 2011. PMID: 21329659 Free PMC article.

9

In vivo and in vitro characterization of a first-in-class novel azole analog that targets pregnane X receptor activation.

Venkatesh M, Wang H, Cayer J, Leroux M, Salvail D, Das B, Wrobel JE, Mani S. Venkatesh M, et al. Among authors: mani s. Mol Pharmacol. 2011 Jul;80(1):124-35. doi: 10.1124/mol.111.071787. Epub 2011 Apr 4. Mol Pharmacol. 2011. PMID: 21464197 Free PMC article.

10

Pregnane X receptor activation induces FGF19-dependent tumor aggressiveness in humans and mice.

Wang H, Venkatesh M, Li H, Goetz R, Mukherjee S, Biswas A, Zhu L, Kaubisch A, Wang L, Pullman J, Whitney K, Kuro-o M, Roig AI, Shay JW, Mohammadi M, Mani S. Wang H, et al. Among authors: mani s. J Clin Invest. 2011 Aug;121(8):3220-32. doi: 10.1172/JCI41514. Epub 2011 Jul 11. J Clin Invest. 2011. PMID: 21747170 Free PMC article.

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My NCBI Filters

Text availability

Article attribute

Article type

Publication date

1,121 results

Search Page