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PARP-1 protects against colorectal tumor induction, but promotes inflammation-driven colorectal tumor progression.
Dörsam B, Seiwert N, Foersch S, Stroh S, Nagel G, Begaliew D, Diehl E, Kraus A, McKeague M, Minneker V, Roukos V, Reißig S, Waisman A, Moehler M, Stier A, Mangerich A, Dantzer F, Kaina B, Fahrer J. Dörsam B, et al. Among authors: mangerich a. Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):E4061-E4070. doi: 10.1073/pnas.1712345115. Epub 2018 Apr 9. Proc Natl Acad Sci U S A. 2018. PMID: 29632181 Free PMC article.
Inflammatory and age-related pathologies in mice with ectopic expression of human PARP-1.
Mangerich A, Herbach N, Hanf B, Fischbach A, Popp O, Moreno-Villanueva M, Bruns OT, Bürkle A. Mangerich A, et al. Mech Ageing Dev. 2010 Jun;131(6):389-404. doi: 10.1016/j.mad.2010.05.005. Epub 2010 Jun 8. Mech Ageing Dev. 2010. PMID: 20561897
PARP-1 is involved in the regulation of genomic integrity, transcription, inflammation, and cell death. Due to its versatile role, PARP-1 is discussed both as a longevity factor and as an aging-promoting factor. Recently, we generated a mouse model with ectopic inte …
PARP-1 is involved in the regulation of genomic integrity, transcription, inflammation, and cell death. Due to its versatile role, PARP-1 is …
Analyzing structure-function relationships of artificial and cancer-associated PARP1 variants by reconstituting TALEN-generated HeLa PARP1 knock-out cells.
Rank L, Veith S, Gwosch EC, Demgenski J, Ganz M, Jongmans MC, Vogel C, Fischbach A, Buerger S, Fischer JM, Zubel T, Stier A, Renner C, Schmalz M, Beneke S, Groettrup M, Kuiper RP, Bürkle A, Ferrando-May E, Mangerich A. Rank L, et al. Among authors: mangerich a. Nucleic Acids Res. 2016 Dec 1;44(21):10386-10405. doi: 10.1093/nar/gkw859. Epub 2016 Sep 29. Nucleic Acids Res. 2016. PMID: 27694308 Free PMC article.
64 results