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Page 1
GnRH replacement rescues cognition in Down syndrome.
Manfredi-Lozano M, Leysen V, Adamo M, Paiva I, Rovera R, Pignat JM, Timzoura FE, Candlish M, Eddarkaoui S, Malone SA, Silva MSB, Trova S, Imbernon M, Decoster L, Cotellessa L, Tena-Sempere M, Claret M, Paoloni-Giacobino A, Plassard D, Paccou E, Vionnet N, Acierno J, Maceski AM, Lutti A, Pfrieger F, Rasika S, Santoni F, Boehm U, Ciofi P, Buée L, Haddjeri N, Boutillier AL, Kuhle J, Messina A, Draganski B, Giacobini P, Pitteloud N, Prevot V. Manfredi-Lozano M, et al. Science. 2022 Sep 2;377(6610):eabq4515. doi: 10.1126/science.abq4515. Epub 2022 Sep 2. Science. 2022. PMID: 36048943 Free PMC article.
GnRH neurons recruit astrocytes in infancy to facilitate network integration and sexual maturation.
Pellegrino G, Martin M, Allet C, Lhomme T, Geller S, Franssen D, Mansuy V, Manfredi-Lozano M, Coutteau-Robles A, Delli V, Rasika S, Mazur D, Loyens A, Tena-Sempere M, Siepmann J, Pralong FP, Ciofi P, Corfas G, Parent AS, Ojeda SR, Sharif A, Prevot V. Pellegrino G, et al. Among authors: manfredi lozano m. Nat Neurosci. 2021 Dec;24(12):1660-1672. doi: 10.1038/s41593-021-00960-z. Epub 2021 Nov 18. Nat Neurosci. 2021. PMID: 34795451
Direct Actions of Kisspeptins on GnRH Neurons Permit Attainment of Fertility but are Insufficient to Fully Preserve Gonadotropic Axis Activity.
León S, Barroso A, Vázquez MJ, García-Galiano D, Manfredi-Lozano M, Ruiz-Pino F, Heras V, Romero-Ruiz A, Roa J, Schutz G, Kirilov M, Gaytan F, Pinilla L, Tena-Sempere M. León S, et al. Among authors: manfredi lozano m. Sci Rep. 2016 Jan 12;6:19206. doi: 10.1038/srep19206. Sci Rep. 2016. PMID: 26755241 Free PMC article.
Kisspeptin treatment induces gonadotropic responses and rescues ovulation in a subset of preclinical models and women with polycystic ovary syndrome.
Romero-Ruiz A, Skorupskaite K, Gaytan F, Torres E, Perdices-Lopez C, Mannaerts BM, Qi S, Leon S, Manfredi-Lozano M, Lopez-Rodriguez C, Avendaño MS, Sanchez-Garrido MA, Vazquez MJ, Pinilla L, van Duin M, Kohout TA, Anderson RA, Tena-Sempere M. Romero-Ruiz A, et al. Among authors: manfredi lozano m. Hum Reprod. 2019 Dec 1;34(12):2495-2512. doi: 10.1093/humrep/dez205. Hum Reprod. 2019. PMID: 31820802 Free PMC article. Clinical Trial.
Hypothalamic miR-30 regulates puberty onset via repression of the puberty-suppressing factor, Mkrn3.
Heras V, Sangiao-Alvarellos S, Manfredi-Lozano M, Sanchez-Tapia MJ, Ruiz-Pino F, Roa J, Lara-Chica M, Morrugares-Carmona R, Jouy N, Abreu AP, Prevot V, Belsham D, Vazquez MJ, Calzado MA, Pinilla L, Gaytan F, Latronico AC, Kaiser UB, Castellano JM, Tena-Sempere M. Heras V, et al. Among authors: manfredi lozano m. PLoS Biol. 2019 Nov 7;17(11):e3000532. doi: 10.1371/journal.pbio.3000532. eCollection 2019 Nov. PLoS Biol. 2019. PMID: 31697675 Free PMC article.
23 results