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Chemogenomics identifies acetyl-coenzyme A synthetase as a target for malaria treatment and prevention.
Cell Chem Biol. 2022 Feb 17;29(2):191-201.e8. doi: 10.1016/j.chembiol.2021.07.010. Epub 2021 Aug 3.
Cell Chem Biol. 2022.
PMID: 34348113
Free PMC article.
Identification of Collateral Sensitivity to Dihydroorotate Dehydrogenase Inhibitors in Plasmodium falciparum.
Ross LS, Lafuente-Monasterio MJ, Sakata-Kato T, Mandt REK, Gamo FJ, Wirth DF, Lukens AK.
Ross LS, et al. Among authors: mandt rek.
ACS Infect Dis. 2018 Apr 13;4(4):508-515. doi: 10.1021/acsinfecdis.7b00217. Epub 2018 Jan 22.
ACS Infect Dis. 2018.
PMID: 29336544
Free PMC article.
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In vitro selection predicts malaria parasite resistance to dihydroorotate dehydrogenase inhibitors in a mouse infection model.
Mandt REK, Lafuente-Monasterio MJ, Sakata-Kato T, Luth MR, Segura D, Pablos-Tanarro A, Viera S, Magan N, Ottilie S, Winzeler EA, Lukens AK, Gamo FJ, Wirth DF.
Mandt REK, et al.
Sci Transl Med. 2019 Dec 4;11(521):eaav1636. doi: 10.1126/scitranslmed.aav1636.
Sci Transl Med. 2019.
PMID: 31801884
Free PMC article.
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Plasmodium gametocytes display homing and vascular transmigration in the host bone marrow.
De Niz M, Meibalan E, Mejia P, Ma S, Brancucci NMB, Agop-Nersesian C, Mandt R, Ngotho P, Hughes KR, Waters AP, Huttenhower C, Mitchell JR, Martinelli R, Frischknecht F, Seydel KB, Taylor T, Milner D, Heussler VT, Marti M.
De Niz M, et al.
Sci Adv. 2018 May 23;4(5):eaat3775. doi: 10.1126/sciadv.aat3775. eCollection 2018 May.
Sci Adv. 2018.
PMID: 29806032
Free PMC article.
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Resistance to Second-Generation HIV-1 Maturation Inhibitors.
Urano E, Timilsina U, Kaplan JA, Ablan S, Ghimire D, Pham P, Kuruppu N, Mandt R, Durell SR, Nitz TJ, Martin DE, Wild CT, Gaur R, Freed EO.
Urano E, et al.
J Virol. 2019 Mar 5;93(6):e02017-18. doi: 10.1128/JVI.02017-18. Print 2019 Mar 15.
J Virol. 2019.
PMID: 30567982
Free PMC article.
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Alkyl Amine Bevirimat Derivatives Are Potent and Broadly Active HIV-1 Maturation Inhibitors.
Urano E, Ablan SD, Mandt R, Pauly GT, Sigano DM, Schneider JP, Martin DE, Nitz TJ, Wild CT, Freed EO.
Urano E, et al.
Antimicrob Agents Chemother. 2015 Oct 19;60(1):190-7. doi: 10.1128/AAC.02121-15. Print 2016 Jan.
Antimicrob Agents Chemother. 2015.
PMID: 26482309
Free PMC article.
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Diverse evolutionary pathways challenge the use of collateral sensitivity as a strategy to suppress resistance.
Mandt REK, Luth MR, Tye MA, Mazitschek R, Ottilie S, Winzeler EA, Lafuente-Monasterio MJ, Gamo FJ, Wirth DF, Lukens AK.
Mandt REK, et al.
Elife. 2023 Sep 22;12:e85023. doi: 10.7554/eLife.85023.
Elife. 2023.
PMID: 37737220
Free PMC article.
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