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A guiding map for inflammation.
Netea MG, Balkwill F, Chonchol M, Cominelli F, Donath MY, Giamarellos-Bourboulis EJ, Golenbock D, Gresnigt MS, Heneka MT, Hoffman HM, Hotchkiss R, Joosten LAB, Kastner DL, Korte M, Latz E, Libby P, Mandrup-Poulsen T, Mantovani A, Mills KHG, Nowak KL, O'Neill LA, Pickkers P, van der Poll T, Ridker PM, Schalkwijk J, Schwartz DA, Siegmund B, Steer CJ, Tilg H, van der Meer JWM, van de Veerdonk FL, Dinarello CA. Netea MG, et al. Nat Immunol. 2017 Jul 19;18(8):826-831. doi: 10.1038/ni.3790. Nat Immunol. 2017. PMID: 28722720 Free PMC article.
Glucose- and interleukin-1beta-induced beta-cell apoptosis requires Ca2+ influx and extracellular signal-regulated kinase (ERK) 1/2 activation and is prevented by a sulfonylurea receptor 1/inwardly rectifying K+ channel 6.2 (SUR/Kir6.2) selective potassium channel opener in human islets.
Maedler K, Størling J, Sturis J, Zuellig RA, Spinas GA, Arkhammar PO, Mandrup-Poulsen T, Donath MY. Maedler K, et al. Diabetes. 2004 Jul;53(7):1706-13. doi: 10.2337/diabetes.53.7.1706. Diabetes. 2004. PMID: 15220194
Interleukin-1-receptor antagonist in type 2 diabetes mellitus.
Larsen CM, Faulenbach M, Vaag A, Vølund A, Ehses JA, Seifert B, Mandrup-Poulsen T, Donath MY. Larsen CM, et al. N Engl J Med. 2007 Apr 12;356(15):1517-26. doi: 10.1056/NEJMoa065213. N Engl J Med. 2007. PMID: 17429083 Free article. Clinical Trial.
Blockade of interleukin 1 in type 1 diabetes mellitus.
Mandrup-Poulsen T, Pickersgill L, Donath MY. Mandrup-Poulsen T, et al. Nat Rev Endocrinol. 2010 Mar;6(3):158-66. doi: 10.1038/nrendo.2009.271. Nat Rev Endocrinol. 2010. PMID: 20173777 Review.
Role of IL-1beta in type 2 diabetes.
Dinarello CA, Donath MY, Mandrup-Poulsen T. Dinarello CA, et al. Curr Opin Endocrinol Diabetes Obes. 2010 Aug;17(4):314-21. doi: 10.1097/MED.0b013e32833bf6dc. Curr Opin Endocrinol Diabetes Obes. 2010. PMID: 20588114 Review.
305 results