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Tau protein liquid-liquid phase separation can initiate tau aggregation.
Wegmann S, Eftekharzadeh B, Tepper K, Zoltowska KM, Bennett RE, Dujardin S, Laskowski PR, MacKenzie D, Kamath T, Commins C, Vanderburg C, Roe AD, Fan Z, Molliex AM, Hernandez-Vega A, Muller D, Hyman AA, Mandelkow E, Taylor JP, Hyman BT. Wegmann S, et al. Among authors: mandelkow e. EMBO J. 2018 Apr 3;37(7):e98049. doi: 10.15252/embj.201798049. Epub 2018 Feb 22. EMBO J. 2018. PMID: 29472250 Free PMC article.
The potential for beta-structure in the repeat domain of tau protein determines aggregation, synaptic decay, neuronal loss, and coassembly with endogenous Tau in inducible mouse models of tauopathy.
Mocanu MM, Nissen A, Eckermann K, Khlistunova I, Biernat J, Drexler D, Petrova O, Schönig K, Bujard H, Mandelkow E, Zhou L, Rune G, Mandelkow EM. Mocanu MM, et al. Among authors: mandelkow em, mandelkow e. J Neurosci. 2008 Jan 16;28(3):737-48. doi: 10.1523/JNEUROSCI.2824-07.2008. J Neurosci. 2008. PMID: 18199773 Free PMC article.
Inhibition of tau aggregation in cell models of tauopathy.
Khlistunova I, Pickhardt M, Biernat J, Wang Y, Mandelkow EM, Mandelkow E. Khlistunova I, et al. Among authors: mandelkow em, mandelkow e. Curr Alzheimer Res. 2007 Dec;4(5):544-6. doi: 10.2174/156720507783018307. Curr Alzheimer Res. 2007. PMID: 18220518 Review.
369 results