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Transcription of the NKG2D ligand MICA is suppressed by the IRE1/XBP1 pathway of the unfolded protein response through the regulation of E2F1.
Obiedat A, Seidel E, Mahameed M, Berhani O, Tsukerman P, Voutetakis K, Chatziioannou A, McMahon M, Avril T, Chevet E, Mandelboim O, Tirosh B. Obiedat A, et al. Among authors: mandelboim o. FASEB J. 2019 Mar;33(3):3481-3495. doi: 10.1096/fj.201801350RR. Epub 2018 Nov 19. FASEB J. 2019. PMID: 30452881
Because of the importance of E2F1 and MICA in cancer progression and recognition, these observations could be exploited for cancer therapy by manipulating the UPR in tumor cells.-Obiedat, A., Seidel, E., Mahameed, M., Berhani, O., Tsukerman, P., Voutetakis, K., Chatziioann …
Because of the importance of E2F1 and MICA in cancer progression and recognition, these observations could be exploited for cancer therapy b …
Host immune system gene targeting by a viral miRNA.
Stern-Ginossar N, Elefant N, Zimmermann A, Wolf DG, Saleh N, Biton M, Horwitz E, Prokocimer Z, Prichard M, Hahn G, Goldman-Wohl D, Greenfield C, Yagel S, Hengel H, Altuvia Y, Margalit H, Mandelboim O. Stern-Ginossar N, et al. Among authors: mandelboim o. Science. 2007 Jul 20;317(5836):376-81. doi: 10.1126/science.1140956. Science. 2007. PMID: 17641203 Free PMC article.
An integrated view of the regulation of NKG2D ligands.
Stern-Ginossar N, Mandelboim O. Stern-Ginossar N, et al. Among authors: mandelboim o. Immunology. 2009 Sep;128(1):1-6. doi: 10.1111/j.1365-2567.2009.03147.x. Immunology. 2009. PMID: 19689730 Free PMC article. Review.
MiRNA-mediated control of HLA-G expression and function.
Manaster I, Goldman-Wohl D, Greenfield C, Nachmani D, Tsukerman P, Hamani Y, Yagel S, Mandelboim O. Manaster I, et al. Among authors: mandelboim o. PLoS One. 2012;7(3):e33395. doi: 10.1371/journal.pone.0033395. Epub 2012 Mar 16. PLoS One. 2012. PMID: 22438923 Free PMC article.
Elucidating the mechanisms of influenza virus recognition by Ncr1.
Glasner A, Zurunic A, Meningher T, Lenac Rovis T, Tsukerman P, Bar-On Y, Yamin R, Meyers AF, Mandeboim M, Jonjic S, Mandelboim O. Glasner A, et al. Among authors: mandelboim o. PLoS One. 2012;7(5):e36837. doi: 10.1371/journal.pone.0036837. Epub 2012 May 15. PLoS One. 2012. PMID: 22615821 Free PMC article.
257 results