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A universal GlycoDesign for lysosomal replacement enzymes to improve circulation time and biodistribution.
Chen YH, Tian W, Yasuda M, Ye Z, Song M, Mandel U, Kristensen C, Povolo L, Marques ARA, Čaval T, Heck AJR, Sampaio JL, Johannes L, Tsukimura T, Desnick R, Vakhrushev SY, Yang Z, Clausen H. Chen YH, et al. Among authors: mandel u. Front Bioeng Biotechnol. 2023 Feb 24;11:1128371. doi: 10.3389/fbioe.2023.1128371. eCollection 2023. Front Bioeng Biotechnol. 2023. PMID: 36911201 Free PMC article.
The glycosylation design space for recombinant lysosomal replacement enzymes produced in CHO cells.
Tian W, Ye Z, Wang S, Schulz MA, Van Coillie J, Sun L, Chen YH, Narimatsu Y, Hansen L, Kristensen C, Mandel U, Bennett EP, Jabbarzadeh-Tabrizi S, Schiffmann R, Shen JS, Vakhrushev SY, Clausen H, Yang Z. Tian W, et al. Among authors: mandel u. Nat Commun. 2019 Apr 30;10(1):1785. doi: 10.1038/s41467-019-09809-3. Nat Commun. 2019. PMID: 31040271 Free PMC article.
Probing isoform-specific functions of polypeptide GalNAc-transferases using zinc finger nuclease glycoengineered SimpleCells.
Schjoldager KT, Vakhrushev SY, Kong Y, Steentoft C, Nudelman AS, Pedersen NB, Wandall HH, Mandel U, Bennett EP, Levery SB, Clausen H. Schjoldager KT, et al. Among authors: mandel u. Proc Natl Acad Sci U S A. 2012 Jun 19;109(25):9893-8. doi: 10.1073/pnas.1203563109. Epub 2012 May 7. Proc Natl Acad Sci U S A. 2012. PMID: 22566642 Free PMC article.
Characterization of binding epitopes of CA125 monoclonal antibodies.
Marcos-Silva L, Narimatsu Y, Halim A, Campos D, Yang Z, Tarp MA, Pereira PJ, Mandel U, Bennett EP, Vakhrushev SY, Levery SB, David L, Clausen H. Marcos-Silva L, et al. Among authors: mandel u. J Proteome Res. 2014 Jul 3;13(7):3349-59. doi: 10.1021/pr500215g. Epub 2014 Jun 4. J Proteome Res. 2014. PMID: 24850311
An Atlas of Human Glycosylation Pathways Enables Display of the Human Glycome by Gene Engineered Cells.
Narimatsu Y, Joshi HJ, Nason R, Van Coillie J, Karlsson R, Sun L, Ye Z, Chen YH, Schjoldager KT, Steentoft C, Furukawa S, Bensing BA, Sullam PM, Thompson AJ, Paulson JC, Büll C, Adema GJ, Mandel U, Hansen L, Bennett EP, Varki A, Vakhrushev SY, Yang Z, Clausen H. Narimatsu Y, et al. Among authors: mandel u. Mol Cell. 2019 Jul 25;75(2):394-407.e5. doi: 10.1016/j.molcel.2019.05.017. Epub 2019 Jun 18. Mol Cell. 2019. PMID: 31227230 Free PMC article.
Display of the human mucinome with defined O-glycans by gene engineered cells.
Nason R, Büll C, Konstantinidi A, Sun L, Ye Z, Halim A, Du W, Sørensen DM, Durbesson F, Furukawa S, Mandel U, Joshi HJ, Dworkin LA, Hansen L, David L, Iverson TM, Bensing BA, Sullam PM, Varki A, Vries E, de Haan CAM, Vincentelli R, Henrissat B, Vakhrushev SY, Clausen H, Narimatsu Y. Nason R, et al. Among authors: mandel u. Nat Commun. 2021 Jul 1;12(1):4070. doi: 10.1038/s41467-021-24366-4. Nat Commun. 2021. PMID: 34210959 Free PMC article.
Precision mapping of the human O-GalNAc glycoproteome through SimpleCell technology.
Steentoft C, Vakhrushev SY, Joshi HJ, Kong Y, Vester-Christensen MB, Schjoldager KT, Lavrsen K, Dabelsteen S, Pedersen NB, Marcos-Silva L, Gupta R, Bennett EP, Mandel U, Brunak S, Wandall HH, Levery SB, Clausen H. Steentoft C, et al. Among authors: mandel u. EMBO J. 2013 May 15;32(10):1478-88. doi: 10.1038/emboj.2013.79. Epub 2013 Apr 12. EMBO J. 2013. PMID: 23584533 Free PMC article.
128 results