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ANKRD26 is a new regulator of type I cytokine receptor signaling in normal and pathological hematopoiesis.
Basso-Valentina F, Donada A, Manchev VT, Lisetto M, Balayn N, Martin JE, Muller D, Oyarzun CPM, Duparc H, Arkoun B, Cumin A, Faivre L, Droin N, Biunno I, Pecci A, Balduini A, Debili N, Antony-Debré I, Marty C, Vainchenker W, Plo I, Favier R, Raslova H. Basso-Valentina F, et al. Among authors: manchev vt. Haematologica. 2023 Aug 1;108(8):2130-2145. doi: 10.3324/haematol.2022.282049. Haematologica. 2023. PMID: 36794499 Free PMC article.
Acquired TET2 mutation in one patient with familial platelet disorder with predisposition to AML led to the development of pre-leukaemic clone resulting in T2-ALL and AML-M0.
Manchev VT, Bouzid H, Antony-Debré I, Leite B, Meurice G, Droin N, Prebet T, Costello RT, Vainchenker W, Plo I, Diop M, Macintyre E, Asnafi V, Favier R, Baccini V, Raslova H. Manchev VT, et al. J Cell Mol Med. 2017 Jun;21(6):1237-1242. doi: 10.1111/jcmm.13051. Epub 2016 Dec 20. J Cell Mol Med. 2017. PMID: 27997762 Free PMC article.
Level of RUNX1 activity is critical for leukemic predisposition but not for thrombocytopenia.
Antony-Debré I, Manchev VT, Balayn N, Bluteau D, Tomowiak C, Legrand C, Langlois T, Bawa O, Tosca L, Tachdjian G, Leheup B, Debili N, Plo I, Mills JA, French DL, Weiss MJ, Solary E, Favier R, Vainchenker W, Raslova H. Antony-Debré I, et al. Among authors: manchev vt. Blood. 2015 Feb 5;125(6):930-40. doi: 10.1182/blood-2014-06-585513. Epub 2014 Dec 9. Blood. 2015. PMID: 25490895 Free PMC article.
A new form of macrothrombocytopenia induced by a germ-line mutation in the PRKACG gene.
Manchev VT, Hilpert M, Berrou E, Elaib Z, Aouba A, Boukour S, Souquere S, Pierron G, Rameau P, Andrews R, Lanza F, Bobe R, Vainchenker W, Rosa JP, Bryckaert M, Debili N, Favier R, Raslova H. Manchev VT, et al. Blood. 2014 Oct 16;124(16):2554-63. doi: 10.1182/blood-2014-01-551820. Epub 2014 Jul 24. Blood. 2014. PMID: 25061177 Free PMC article.
Phase variable genes of Campylobacter jejuni exhibit high mutation rates and specific mutational patterns but mutability is not the major determinant of population structure during host colonization.
Bayliss CD, Bidmos FA, Anjum A, Manchev VT, Richards RL, Grossier JP, Wooldridge KG, Ketley JM, Barrow PA, Jones MA, Tretyakov MV. Bayliss CD, et al. Among authors: manchev vt. Nucleic Acids Res. 2012 Jul;40(13):5876-89. doi: 10.1093/nar/gks246. Epub 2012 Mar 20. Nucleic Acids Res. 2012. PMID: 22434884 Free PMC article.