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Functional HIV-1/HCV cross-reactive antibodies isolated from a chronically co-infected donor.
Pilewski KA, Wall S, Richardson SI, Manamela NP, Clark K, Hermanus T, Binshtein E, Venkat R, Sautto GA, Kramer KJ, Shiakolas AR, Setliff I, Salas J, Mapengo RE, Suryadevara N, Brannon JR, Beebout CJ, Parks R, Raju N, Frumento N, Walker LM, Fechter EF, Qin JS, Murji AA, Janowska K, Thakur B, Lindenberger J, May AJ, Huang X, Sammour S, Acharya P, Carnahan RH, Ross TM, Haynes BF, Hadjifrangiskou M, Crowe JE Jr, Bailey JR, Kalams S, Morris L, Georgiev IS. Pilewski KA, et al. Among authors: manamela np. Cell Rep. 2023 Feb 28;42(2):112044. doi: 10.1016/j.celrep.2023.112044. Epub 2023 Jan 27. Cell Rep. 2023. PMID: 36708513 Free PMC article.
Cross-reactive coronavirus antibodies with diverse epitope specificities and extra-neutralization functions.
Shiakolas AR, Kramer KJ, Wrapp D, Richardson SI, Schäfer A, Wall S, Wang N, Janowska K, Pilewski KA, Venkat R, Parks R, Manamela NP, Raju N, Fechter EF, Holt CM, Suryadevara N, Chen RE, Martinez DR, Nargi RS, Sutton RE, Ledgerwood JE, Graham BS, Diamond MS, Haynes BF, Acharya P, Carnahan RH, Crowe JE, Baric RS, Morris L, McLellan JS, Georgiev IS. Shiakolas AR, et al. Among authors: manamela np. bioRxiv [Preprint]. 2020 Dec 20:2020.12.20.414748. doi: 10.1101/2020.12.20.414748. bioRxiv. 2020. PMID: 33398266 Free PMC article. Updated. Preprint.
Cross-reactive coronavirus antibodies with diverse epitope specificities and Fc effector functions.
Shiakolas AR, Kramer KJ, Wrapp D, Richardson SI, Schäfer A, Wall S, Wang N, Janowska K, Pilewski KA, Venkat R, Parks R, Manamela NP, Raju N, Fechter EF, Holt CM, Suryadevara N, Chen RE, Martinez DR, Nargi RS, Sutton RE, Ledgerwood JE, Graham BS, Diamond MS, Haynes BF, Acharya P, Carnahan RH, Crowe JE Jr, Baric RS, Morris L, McLellan JS, Georgiev IS. Shiakolas AR, et al. Among authors: manamela np. Cell Rep Med. 2021 Jun 15;2(6):100313. doi: 10.1016/j.xcrm.2021.100313. Epub 2021 May 21. Cell Rep Med. 2021. PMID: 34056628 Free PMC article.
Prior infection with SARS-CoV-2 boosts and broadens Ad26.COV2.S immunogenicity in a variant-dependent manner.
Keeton R, Richardson SI, Moyo-Gwete T, Hermanus T, Tincho MB, Benede N, Manamela NP, Baguma R, Makhado Z, Ngomti A, Motlou T, Mennen M, Chinhoyi L, Skelem S, Maboreke H, Doolabh D, Iranzadeh A, Otter AD, Brooks T, Noursadeghi M, Moon JC, Grifoni A, Weiskopf D, Sette A, Blackburn J, Hsiao NY, Williamson C, Riou C, Goga A, Garrett N, Bekker LG, Gray G, Ntusi NAB, Moore PL, Burgers WA. Keeton R, et al. Among authors: manamela np. Cell Host Microbe. 2021 Nov 10;29(11):1611-1619.e5. doi: 10.1016/j.chom.2021.10.003. Epub 2021 Oct 13. Cell Host Microbe. 2021. PMID: 34688376 Free PMC article.
SARS-CoV-2 Beta and Delta variants trigger Fc effector function with increased cross-reactivity.
Richardson SI, Manamela NP, Motsoeneng BM, Kaldine H, Ayres F, Makhado Z, Mennen M, Skelem S, Williams N, Sullivan NJ, Misasi J, Gray GG, Bekker LG, Ueckermann V, Rossouw TM, Boswell MT, Ntusi NAB, Burgers WA, Moore PL. Richardson SI, et al. Among authors: manamela np. Cell Rep Med. 2022 Jan 17;3(2):100510. doi: 10.1016/j.xcrm.2022.100510. eCollection 2022 Feb 15. Cell Rep Med. 2022. PMID: 35233544 Free PMC article.
SARS-CoV-2 Omicron triggers cross-reactive neutralization and Fc effector functions in previously vaccinated, but not unvaccinated, individuals.
Richardson SI, Madzorera VS, Spencer H, Manamela NP, van der Mescht MA, Lambson BE, Oosthuysen B, Ayres F, Makhado Z, Moyo-Gwete T, Mzindle N, Motlou T, Strydom A, Mendes A, Tegally H, de Beer Z, Roma de Villiers T, Bodenstein A, van den Berg G, Venter M, de Oliviera T, Ueckermann V, Rossouw TM, Boswell MT, Moore PL. Richardson SI, et al. Among authors: manamela np. Cell Host Microbe. 2022 Jun 8;30(6):880-886.e4. doi: 10.1016/j.chom.2022.03.029. Epub 2022 Mar 25. Cell Host Microbe. 2022. PMID: 35436444 Free PMC article.
Ad26.COV2.S breakthrough infections induce high titers of neutralizing antibodies against Omicron and other SARS-CoV-2 variants of concern.
Kitchin D, Richardson SI, van der Mescht MA, Motlou T, Mzindle N, Moyo-Gwete T, Makhado Z, Ayres F, Manamela NP, Spencer H, Lambson B, Oosthuysen B, Kaldine H, du Pisanie M, Mennen M, Skelem S, Williams N, Ntusi NAB, Burgers WA, Gray GG, Bekker LG, Boswell MT, Rossouw TM, Ueckermann V, Moore PL. Kitchin D, et al. Among authors: manamela np. Cell Rep Med. 2022 Feb 10;3(3):100535. doi: 10.1016/j.xcrm.2022.100535. eCollection 2022 Mar 15. Cell Rep Med. 2022. PMID: 35474744 Free PMC article.
Shared N417-Dependent Epitope on the SARS-CoV-2 Omicron, Beta, and Delta Plus Variants.
Moyo-Gwete T, Madzivhandila M, Mkhize NN, Kgagudi P, Ayres F, Lambson BE, Manamela NP, Richardson SI, Makhado Z, van der Mescht MA, de Beer Z, de Villiers TR, Burgers WA, Ntusi NAB, Rossouw T, Ueckermann V, Boswell MT, Moore PL. Moyo-Gwete T, et al. Among authors: manamela np. J Virol. 2022 Aug 10;96(15):e0055822. doi: 10.1128/jvi.00558-22. Epub 2022 Jul 13. J Virol. 2022. PMID: 35867572 Free PMC article.
Enhanced neutralization potency of an identical HIV neutralizing antibody expressed as different isotypes is achieved through genetically distinct mechanisms.
Moyo-Gwete T, Scheepers C, Makhado Z, Kgagudi P, Mzindle NB, Ziki R, Madzorera S, Manamela NP, Ayres F, Lambson BE, Richardson SI, Morris L, Moore PL. Moyo-Gwete T, et al. Among authors: manamela np. Sci Rep. 2022 Oct 1;12(1):16473. doi: 10.1038/s41598-022-20141-7. Sci Rep. 2022. PMID: 36182959 Free PMC article.
21 results