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CXCR2 increases in ALS cortical neurons and its inhibition prevents motor neuron degeneration in vitro and improves neuromuscular function in SOD1G93A mice.
La Cognata V, Golini E, Iemmolo R, Balletta S, Morello G, De Rosa C, Villari A, Marinelli S, Vacca V, Bonaventura G, Dell'Albani P, Aronica E, Mammano F, Mandillo S, Cavallaro S. La Cognata V, et al. Among authors: mammano f. Neurobiol Dis. 2021 Dec;160:105538. doi: 10.1016/j.nbd.2021.105538. Epub 2021 Oct 29. Neurobiol Dis. 2021. PMID: 34743985 Free article.
Cx26 partial loss causes accelerated presbycusis by redox imbalance and dysregulation of Nfr2 pathway.
Fetoni AR, Zorzi V, Paciello F, Ziraldo G, Peres C, Raspa M, Scavizzi F, Salvatore AM, Crispino G, Tognola G, Gentile G, Spampinato AG, Cuccaro D, Guarnaccia M, Morello G, Van Camp G, Fransen E, Brumat M, Girotto G, Paludetti G, Gasparini P, Cavallaro S, Mammano F. Fetoni AR, et al. Among authors: mammano f. Redox Biol. 2018 Oct;19:301-317. doi: 10.1016/j.redox.2018.08.002. Epub 2018 Aug 7. Redox Biol. 2018. PMID: 30199819 Free PMC article.
miRNA and mRNA Profiling Links Connexin Deficiency to Deafness via Early Oxidative Damage in the Mouse Stria Vascularis.
Gentile G, Paciello F, Zorzi V, Spampinato AG, Guarnaccia M, Crispino G, Tettey-Matey A, Scavizzi F, Raspa M, Fetoni AR, Cavallaro S, Mammano F. Gentile G, et al. Among authors: mammano f. Front Cell Dev Biol. 2021 Jan 25;8:616878. doi: 10.3389/fcell.2020.616878. eCollection 2020. Front Cell Dev Biol. 2021. PMID: 33569381 Free PMC article.
A potent antagonist antibody targeting connexin hemichannels alleviates Clouston syndrome symptoms in mutant mice.
Kuang Y, Zorzi V, Buratto D, Ziraldo G, Mazzarda F, Peres C, Nardin C, Salvatore AM, Chiani F, Scavizzi F, Raspa M, Qiang M, Chu Y, Shi X, Li Y, Liu L, Shi Y, Zonta F, Yang G, Lerner RA, Mammano F. Kuang Y, et al. Among authors: mammano f. EBioMedicine. 2020 Jul;57:102825. doi: 10.1016/j.ebiom.2020.102825. Epub 2020 Jun 15. EBioMedicine. 2020. PMID: 32553574 Free PMC article.
The p.Cys169Tyr variant of connexin 26 is not a polymorphism.
Zonta F, Girotto G, Buratto D, Crispino G, Morgan A, Abdulhadi K, Alkowari M, Badii R, Gasparini P, Mammano F. Zonta F, et al. Among authors: mammano f. Hum Mol Genet. 2015 May 1;24(9):2641-8. doi: 10.1093/hmg/ddv026. Epub 2015 Jan 26. Hum Mol Genet. 2015. PMID: 25628337 Free PMC article.
188 results