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HIF-1α is a protective factor in conditional PHD2-deficient mice suffering from severe HIF-2α-induced excessive erythropoiesis.
Franke K, Kalucka J, Mamlouk S, Singh RP, Muschter A, Weidemann A, Iyengar V, Jahn S, Wieczorek K, Geiger K, Muders M, Sykes AM, Poitz DM, Ripich T, Otto T, Bergmann S, Breier G, Baretton G, Fong GH, Greaves DR, Bornstein S, Chavakis T, Fandrey J, Gassmann M, Wielockx B. Franke K, et al. Among authors: mamlouk s. Blood. 2013 Feb 21;121(8):1436-45. doi: 10.1182/blood-2012-08-449181. Epub 2012 Dec 20. Blood. 2013. PMID: 23264599 Free PMC article.
HIF prolyl hydroxylase 2 (PHD2) is a critical regulator of hematopoietic stem cell maintenance during steady-state and stress.
Singh RP, Franke K, Kalucka J, Mamlouk S, Muschter A, Gembarska A, Grinenko T, Willam C, Naumann R, Anastassiadis K, Stewart AF, Bornstein S, Chavakis T, Breier G, Waskow C, Wielockx B. Singh RP, et al. Among authors: mamlouk s. Blood. 2013 Jun 27;121(26):5158-66. doi: 10.1182/blood-2012-12-471185. Epub 2013 May 10. Blood. 2013. PMID: 23667053 Free article.
Clonality and timing of relapsing colorectal cancer metastasis revealed through whole-genome single-cell sequencing.
Alves JM, Prado-López S, Tomás L, Valecha M, Estévez-Gómez N, Alvariño P, Geisel D, Modest DP, Sauer IM, Pratschke J, Raschzok N, Sers C, Mamlouk S, Posada D. Alves JM, et al. Among authors: mamlouk s. Cancer Lett. 2022 Sep 1;543:215767. doi: 10.1016/j.canlet.2022.215767. Epub 2022 Jun 7. Cancer Lett. 2022. PMID: 35688262 Free article.
The majority of β-catenin mutations in colorectal cancer is homozygous.
Arnold A, Tronser M, Sers C, Ahadova A, Endris V, Mamlouk S, Horst D, Möbs M, Bischoff P, Kloor M, Bläker H. Arnold A, et al. Among authors: mamlouk s. BMC Cancer. 2020 Oct 28;20(1):1038. doi: 10.1186/s12885-020-07537-2. BMC Cancer. 2020. PMID: 33115416 Free PMC article.
Serial Analysis of Gene Mutations and Gene Expression during First-Line Chemotherapy against Metastatic Colorectal Cancer: Identification of Potentially Actionable Targets within the Multicenter Prospective Biomarker Study REVEAL.
Kumbrink J, Bohlmann L, Mamlouk S, Redmer T, Peilstöcker D, Li P, Lorenzen S, Algül H, Kasper S, Hempel D, Kaiser F, Michl M, Bartsch H, Neumann J, Klauschen F, von Bergwelt-Baildon M, Modest DP, Stahler A, Stintzing S, Jung A, Kirchner T, Schäfer R, Heinemann V, Holch JW. Kumbrink J, et al. Among authors: mamlouk s. Cancers (Basel). 2022 Jul 26;14(15):3631. doi: 10.3390/cancers14153631. Cancers (Basel). 2022. PMID: 35892888 Free PMC article.
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