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LRRK2 mediates tubulation and vesicle sorting from lysosomes.
Bonet-Ponce L, Beilina A, Williamson CD, Lindberg E, Kluss JH, Saez-Atienzar S, Landeck N, Kumaran R, Mamais A, Bleck CKE, Li Y, Cookson MR. Bonet-Ponce L, et al. Among authors: mamais a. Sci Adv. 2020 Nov 11;6(46):eabb2454. doi: 10.1126/sciadv.abb2454. Print 2020 Nov. Sci Adv. 2020. PMID: 33177079 Free PMC article.
Pathogenic LRRK2 mutations do not alter gene expression in cell model systems or human brain tissue.
Devine MJ, Kaganovich A, Ryten M, Mamais A, Trabzuni D, Manzoni C, McGoldrick P, Chan D, Dillman A, Zerle J, Horan S, Taanman JW, Hardy J, Marti-Masso JF, Healy D, Schapira AH, Wolozin B, Bandopadhyay R, Cookson MR, van der Brug MP, Lewis PA. Devine MJ, et al. Among authors: mamais a. PLoS One. 2011;6(7):e22489. doi: 10.1371/journal.pone.0022489. Epub 2011 Jul 22. PLoS One. 2011. PMID: 21799870 Free PMC article.
Hexokinases link DJ-1 to the PINK1/parkin pathway.
Hauser DN, Mamais A, Conti MM, Primiani CT, Kumaran R, Dillman AA, Langston RG, Beilina A, Garcia JH, Diaz-Ruiz A, Bernier M, Fiesel FC, Hou X, Springer W, Li Y, de Cabo R, Cookson MR. Hauser DN, et al. Among authors: mamais a. Mol Neurodegener. 2017 Sep 29;12(1):70. doi: 10.1186/s13024-017-0212-x. Mol Neurodegener. 2017. PMID: 28962651 Free PMC article.
Proteomic analysis reveals co-ordinated alterations in protein synthesis and degradation pathways in LRRK2 knockout mice.
Pellegrini L, Hauser DN, Li Y, Mamais A, Beilina A, Kumaran R, Wetzel A, Nixon-Abell J, Heaton G, Rudenko I, Alkaslasi M, Ivanina N, Melrose HL, Cookson MR, Harvey K. Pellegrini L, et al. Among authors: mamais a. Hum Mol Genet. 2018 Sep 15;27(18):3257-3271. doi: 10.1093/hmg/ddy232. Hum Mol Genet. 2018. PMID: 29917075 Free PMC article.
42 results