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Investigation into the Mechanism of Action of the Tuberculosis Drug Candidate SQ109 and Its Metabolites and Analogues in Mycobacteria.
Malwal SR, Mazurek B, Ko J, Xie P, Barnes C, Varvitsiotis C, Zimmerman MD, Olatunji S, Lee J, Xie M, Sarathy J, Caffrey M, Strynadka NCJ, Dartois V, Dick T, Lee BNR, Russell DG, Oldfield E. Malwal SR, et al. J Med Chem. 2023 Jun 8;66(11):7553-7569. doi: 10.1021/acs.jmedchem.3c00398. Epub 2023 May 26. J Med Chem. 2023. PMID: 37235809 Free PMC article.
Benzosultines as sulfur dioxide (SO2) donors.
Malwal SR, Gudem M, Hazra A, Chakrapani H. Malwal SR, et al. Org Lett. 2013 Mar 1;15(5):1116-9. doi: 10.1021/ol400190f. Epub 2013 Feb 20. Org Lett. 2013. PMID: 23421429
Isoprenoid Biosynthesis Inhibitors Targeting Bacterial Cell Growth.
Desai J, Wang Y Dr, Wang K Dr, Malwal SR Dr, Oldfield E. Desai J, et al. Among authors: malwal sr dr. ChemMedChem. 2016 Oct 6;11(19):2205-2215. doi: 10.1002/cmdc.201600343. Epub 2016 Aug 30. ChemMedChem. 2016. PMID: 27571880 Free PMC article.
Alkynyl-containing phenylthiazoles: Systemically active antibacterial agents effective against methicillin-resistant Staphylococcus aureus (MRSA).
Elsebaei MM, Mohammad H, Abouf M, Abutaleb NS, Hegazy YA, Ghiaty A, Chen L, Zhang J, Malwal SR, Oldfield E, Seleem MN, Mayhoub AS. Elsebaei MM, et al. Among authors: malwal sr. Eur J Med Chem. 2018 Mar 25;148:195-209. doi: 10.1016/j.ejmech.2018.02.031. Epub 2018 Feb 12. Eur J Med Chem. 2018. PMID: 29459278 Free PMC article.
Bisphosphonate-Generated ATP-Analogs Inhibit Cell Signaling Pathways.
Malwal SR, O'Dowd B, Feng X, Turhanen P, Shin C, Yao J, Kim BK, Baig N, Zhou T, Bansal S, Khade RL, Zhang Y, Oldfield E. Malwal SR, et al. J Am Chem Soc. 2018 Jun 20;140(24):7568-7578. doi: 10.1021/jacs.8b02363. Epub 2018 Jun 5. J Am Chem Soc. 2018. PMID: 29787268 Free PMC article.
30 results