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Improvement of antimalarial activity of a 3-alkylpiridine alkaloid analog by replacing the pyridine ring to a thiazole-containing heterocycle: Mode of action, mutagenicity profile, and Caco-2 cell-based permeability.
Eur J Pharm Sci. 2019 Oct 1;138:105015. doi: 10.1016/j.ejps.2019.105015. Epub 2019 Jul 22.
Eur J Pharm Sci. 2019.
PMID: 31344442
KBE009: An antimalarial bestatin-like inhibitor of the Plasmodium falciparum M1 aminopeptidase discovered in an Ugi multicomponent reaction-derived peptidomimetic library.
González-Bacerio J, Maluf SEC, Méndez Y, Pascual I, Florent I, Melo PMS, Budu A, Ferreira JC, Moreno E, Carmona AK, Rivera DG, Alonso Del Rivero M, Gazarini ML.
González-Bacerio J, et al. Among authors: maluf sec.
Bioorg Med Chem. 2017 Sep 1;25(17):4628-4636. doi: 10.1016/j.bmc.2017.06.047. Epub 2017 Jul 4.
Bioorg Med Chem. 2017.
PMID: 28728898
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Overexpression of Plasmodium falciparum M1 Aminopeptidase Promotes an Increase in Intracellular Proteolysis and Modifies the Asexual Erythrocytic Cycle Development.
Hoff CC, Azevedo MF, Thurler AB, Maluf SEC, Melo PMS, Del Rivero MA, González-Bacerio J, Carmona AK, Budu A, Gazarini ML.
Hoff CC, et al. Among authors: maluf sec.
Pathogens. 2021 Nov 10;10(11):1452. doi: 10.3390/pathogens10111452.
Pathogens. 2021.
PMID: 34832608
Free PMC article.
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Synthesis, Structure−Activity Relationships, and Parasitological Profiling of Brussonol Derivatives as New Plasmodium falciparum Inhibitors.
Barbosa CS, Ahmad A, Maluf SEC, Moura IMR, Souza GE, Guerra GAH, Barros RRM, Gazarini ML, Aguiar ACC, Burtoloso ACB, Guido RVC.
Barbosa CS, et al. Among authors: maluf sec.
Pharmaceuticals (Basel). 2022 Jun 30;15(7):814. doi: 10.3390/ph15070814.
Pharmaceuticals (Basel). 2022.
PMID: 35890113
Free PMC article.
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Discovery of new piperaquine hybrid analogs linked by triazolopyrimidine and pyrazolopyrimidine scaffolds with antiplasmodial and transmission blocking activities.
Feitosa LM, Franca RRF, Ferreira MLG, Aguiar ACC, de Souza GE, Maluf SEC, de Souza JO, Zapata L, Duarte D, Morais I, Nogueira F, Nonato MC, Pinheiro LCS, Guido RVC, Boechat N.
Feitosa LM, et al. Among authors: maluf sec.
Eur J Med Chem. 2024 Mar 5;267:116163. doi: 10.1016/j.ejmech.2024.116163. Epub 2024 Jan 25.
Eur J Med Chem. 2024.
PMID: 38290351
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