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The viral protein corona directs viral pathogenesis and amyloid aggregation.
Ezzat K, Pernemalm M, Pålsson S, Roberts TC, Järver P, Dondalska A, Bestas B, Sobkowiak MJ, Levänen B, Sköld M, Thompson EA, Saher O, Kari OK, Lajunen T, Sverremark Ekström E, Nilsson C, Ishchenko Y, Malm T, Wood MJA, Power UF, Masich S, Lindén A, Sandberg JK, Lehtiö J, Spetz AL, El Andaloussi S. Ezzat K, et al. Among authors: malm t. Nat Commun. 2019 May 27;10(1):2331. doi: 10.1038/s41467-019-10192-2. Nat Commun. 2019. PMID: 31133680 Free PMC article.
Augmentation of Anticancer Drug Efficacy in Murine Hepatocellular Carcinoma Cells by a Peripherally Acting Competitive N-Methyl-d-aspartate (NMDA) Receptor Antagonist.
Gynther M, Proietti Silvestri I, Hansen JC, Hansen KB, Malm T, Ishchenko Y, Larsen Y, Han L, Kayser S, Auriola S, Petsalo A, Nielsen B, Pickering DS, Bunch L. Gynther M, et al. Among authors: malm t. J Med Chem. 2017 Dec 14;60(23):9885-9904. doi: 10.1021/acs.jmedchem.7b01624. Epub 2017 Dec 5. J Med Chem. 2017. PMID: 29205034 Free PMC article.
Disentangling the Amyloid Pathways: A Mechanistic Approach to Etiology.
Malmberg M, Malm T, Gustafsson O, Sturchio A, Graff C, Espay AJ, Wright AP, El Andaloussi S, Lindén A, Ezzat K. Malmberg M, et al. Among authors: malm t. Front Neurosci. 2020 Apr 21;14:256. doi: 10.3389/fnins.2020.00256. eCollection 2020. Front Neurosci. 2020. PMID: 32372895 Free PMC article.
High cerebrospinal amyloid-β 42 is associated with normal cognition in individuals with brain amyloidosis.
Sturchio A, Dwivedi AK, Young CB, Malm T, Marsili L, Sharma JS, Mahajan A, Hill EJ, Andaloussi SE, Poston KL, Manfredsson FP, Schneider LS, Ezzat K, Espay AJ. Sturchio A, et al. Among authors: malm t. EClinicalMedicine. 2021 Jun 28;38:100988. doi: 10.1016/j.eclinm.2021.100988. eCollection 2021 Aug. EClinicalMedicine. 2021. PMID: 34505023 Free PMC article.
Microglial amyloid beta clearance is driven by PIEZO1 channels.
Jäntti H, Sitnikova V, Ishchenko Y, Shakirzyanova A, Giudice L, Ugidos IF, Gómez-Budia M, Korvenlaita N, Ohtonen S, Belaya I, Fazaludeen F, Mikhailov N, Gotkiewicz M, Ketola K, Lehtonen Š, Koistinaho J, Kanninen KM, Hernández D, Pébay A, Giugno R, Korhonen P, Giniatullin R, Malm T. Jäntti H, et al. Among authors: malm t. J Neuroinflammation. 2022 Jun 15;19(1):147. doi: 10.1186/s12974-022-02486-y. J Neuroinflammation. 2022. PMID: 35706029 Free PMC article.
High Soluble Amyloid-β42 Predicts Normal Cognition in Amyloid-Positive Individuals with Alzheimer's Disease-Causing Mutations.
Sturchio A, Dwivedi AK, Malm T, Wood MJA, Cilia R, Sharma JS, Hill EJ, Schneider LS, Graff-Radford NR, Mori H, Nübling G, El Andaloussi S, Svenningsson P, Ezzat K, Espay AJ; Dominantly Inherited Alzheimer Consortia (DIAN). Sturchio A, et al. Among authors: malm t. J Alzheimers Dis. 2022;90(1):333-348. doi: 10.3233/JAD-220808. J Alzheimers Dis. 2022. PMID: 36120786 Free PMC article.
beta-Amyloid infusion results in delayed and age-dependent learning deficits without role of inflammation or beta-amyloid deposits.
Malm T, Ort M, Tähtivaara L, Jukarainen N, Goldsteins G, Puoliväli J, Nurmi A, Pussinen R, Ahtoniemi T, Miettinen TK, Kanninen K, Leskinen S, Vartiainen N, Yrjänheikki J, Laatikainen R, Harris-White ME, Koistinaho M, Frautschy SA, Bures J, Koistinaho J. Malm T, et al. Proc Natl Acad Sci U S A. 2006 Jun 6;103(23):8852-7. doi: 10.1073/pnas.0602896103. Epub 2006 May 24. Proc Natl Acad Sci U S A. 2006. PMID: 16723396 Free PMC article.
Nuclear factor erythroid 2-related factor 2 protects against beta amyloid.
Kanninen K, Malm TM, Jyrkkänen HK, Goldsteins G, Keksa-Goldsteine V, Tanila H, Yamamoto M, Ylä-Herttuala S, Levonen AL, Koistinaho J. Kanninen K, et al. Mol Cell Neurosci. 2008 Nov;39(3):302-13. doi: 10.1016/j.mcn.2008.07.010. Epub 2008 Jul 29. Mol Cell Neurosci. 2008. PMID: 18706502
207 results