Malinak D - Search Results

1

Inhibitors of phosphoinositide 3-kinase (PI3K) and phosphoinositide 3-kinase-related protein kinase family (PIKK).

Huang X, You L, Nepovimova E, Psotka M, Malinak D, Valko M, Sivak L, Korabecny J, Heger Z, Adam V, Wu Q, Kuca K. Huang X, et al. Among authors: malinak d. J Enzyme Inhib Med Chem. 2023 Dec;38(1):2237209. doi: 10.1080/14756366.2023.2237209. J Enzyme Inhib Med Chem. 2023. PMID: 37489050 Free PMC article. Review.

2

6-Hydroxyquinolinium salts differing in the length of alkyl side-chain: synthesis and antimicrobial activity.

Malinak D, Dolezal R, Marek J, Salajkova S, Soukup O, Vejsova M, Korabecny J, Honegr J, Penhaker M, Musilek K, Kuca K. Malinak D, et al. Bioorg Med Chem Lett. 2014 Nov 15;24(22):5238-41. doi: 10.1016/j.bmcl.2014.09.060. Epub 2014 Sep 28. Bioorg Med Chem Lett. 2014. PMID: 25442318

3

Ligand-based 3D QSAR analysis of reactivation potency of mono- and bis-pyridinium aldoximes toward VX-inhibited rat acetylcholinesterase.

Dolezal R, Korabecny J, Malinak D, Honegr J, Musilek K, Kuca K. Dolezal R, et al. Among authors: malinak d. J Mol Graph Model. 2015 Mar;56:113-29. doi: 10.1016/j.jmgm.2014.11.010. Epub 2014 Dec 25. J Mol Graph Model. 2015. PMID: 25588616

4

Synthesis and disinfection effect of the pyridine-4-aldoxime based salts.

Marek J, Malinak D, Dolezal R, Soukup O, Pasdiorova M, Dolezal M, Kuca K. Marek J, et al. Among authors: malinak d. Molecules. 2015 Feb 24;20(3):3681-96. doi: 10.3390/molecules20033681. Molecules. 2015. PMID: 25719739 Free PMC article.

5

Structural Properties of Potential Synthetic Vaccine Adjuvants - TLR Agonists.

Honegr J, Soukup O, Doležal R, Malinak D, Penhaker M, Prymula R, Kuca K. Honegr J, et al. Among authors: malinak d. Curr Med Chem. 2015;22(29):3306-25. doi: 10.2174/0929867322666150821094634. Curr Med Chem. 2015. PMID: 26295466 Review.

6

Tacrine-Trolox Hybrids: A Novel Class of Centrally Active, Nonhepatotoxic Multi-Target-Directed Ligands Exerting Anticholinesterase and Antioxidant Activities with Low In Vivo Toxicity.

Nepovimova E, Korabecny J, Dolezal R, Babkova K, Ondrejicek A, Jun D, Sepsova V, Horova A, Hrabinova M, Soukup O, Bukum N, Jost P, Muckova L, Kassa J, Malinak D, Andrs M, Kuca K. Nepovimova E, et al. Among authors: malinak d. J Med Chem. 2015 Nov 25;58(22):8985-9003. doi: 10.1021/acs.jmedchem.5b01325. Epub 2015 Nov 10. J Med Chem. 2015. PMID: 26503905

7

7-Methoxytacrine-p-Anisidine Hybrids as Novel Dual Binding Site Acetylcholinesterase Inhibitors for Alzheimer's Disease Treatment.

Korabecny J, Andrs M, Nepovimova E, Dolezal R, Babkova K, Horova A, Malinak D, Mezeiova E, Gorecki L, Sepsova V, Hrabinova M, Soukup O, Jun D, Kuca K. Korabecny J, et al. Among authors: malinak d. Molecules. 2015 Dec 10;20(12):22084-101. doi: 10.3390/molecules201219836. Molecules. 2015. PMID: 26690394 Free PMC article.

8

Synthesis, antimicrobial evaluation and molecular modeling of 5-hydroxyisoquinolinium salt series; the effect of the hydroxyl moiety.

Soukup O, Dolezal R, Malinak D, Marek J, Salajkova S, Pasdiorova M, Honegr J, Korabecny J, Nachtigal P, Nachon F, Jun D, Kuca K. Soukup O, et al. Among authors: malinak d. Bioorg Med Chem. 2016 Feb 15;24(4):841-8. doi: 10.1016/j.bmc.2016.01.006. Epub 2016 Jan 6. Bioorg Med Chem. 2016. PMID: 26774252

9

Towards understanding the mechanism of action of antibacterial N-alkyl-3-hydroxypyridinium salts: Biological activities, molecular modeling and QSAR studies.

Dolezal R, Soukup O, Malinak D, Savedra RML, Marek J, Dolezalova M, Pasdiorova M, Salajkova S, Korabecny J, Honegr J, Ramalho TC, Kuca K. Dolezal R, et al. Among authors: malinak d. Eur J Med Chem. 2016 Oct 4;121:699-711. doi: 10.1016/j.ejmech.2016.05.058. Epub 2016 May 30. Eur J Med Chem. 2016. PMID: 27341309

10

SAR study to find optimal cholinesterase reactivator against organophosphorous nerve agents and pesticides.

Gorecki L, Korabecny J, Musilek K, Malinak D, Nepovimova E, Dolezal R, Jun D, Soukup O, Kuca K. Gorecki L, et al. Among authors: malinak d. Arch Toxicol. 2016 Dec;90(12):2831-2859. doi: 10.1007/s00204-016-1827-3. Epub 2016 Aug 31. Arch Toxicol. 2016. PMID: 27582056 Review.

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