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In vitro and in silico Evaluation of Non-Quaternary Reactivators of AChE as Antidotes of Organophosphorus Poisoning - a New Hope or a Blind Alley?
Soukup O, Korabecny J, Malinak D, Nepovimova E, Pham NL, Musilek K, Hrabinova M, Hepnarova V, Dolezal R, Pavek P, Jost P, Kobrlova T, Jankockova J, Gorecki L, Psotka M, Nguyen TD, Box K, Outhwaite B, Ceckova M, Sorf A, Jun D, Kuca K. Soukup O, et al. Among authors: malinak d. Med Chem. 2018;14(3):281-292. doi: 10.2174/1573406414666180112105657. Med Chem. 2018. PMID: 29332594
A 7-methoxytacrine-4-pyridinealdoxime hybrid as a novel prophylactic agent with reactivation properties in organophosphate intoxication.
Nepovimova E, Korabecny J, Dolezal R, Nguyen TD, Jun D, Soukup O, Pasdiorova M, Jost P, Muckova L, Malinak D, Gorecki L, Musilek K, Kuca K. Nepovimova E, et al. Among authors: malinak d. Toxicol Res (Camb). 2016 May 25;5(4):1012-1016. doi: 10.1039/c6tx00130k. eCollection 2016 Jul 1. Toxicol Res (Camb). 2016. PMID: 30090408 Free PMC article.
Pyridinium Oximes with Ortho-Positioned Chlorine Moiety Exhibit Improved Physicochemical Properties and Efficient Reactivation of Human Acetylcholinesterase Inhibited by Several Nerve Agents.
Zorbaz T, Malinak D, Maraković N, Maček Hrvat N, Zandona A, Novotny M, Skarka A, Andrys R, Benkova M, Soukup O, Katalinić M, Kuca K, Kovarik Z, Musilek K. Zorbaz T, et al. Among authors: malinak d. J Med Chem. 2018 Dec 13;61(23):10753-10766. doi: 10.1021/acs.jmedchem.8b01398. Epub 2018 Nov 20. J Med Chem. 2018. PMID: 30383374
Oxime K203: a drug candidate for the treatment of tabun intoxication.
Gorecki L, Soukup O, Kucera T, Malinak D, Jun D, Kuca K, Musilek K, Korabecny J. Gorecki L, et al. Among authors: malinak d. Arch Toxicol. 2019 Mar;93(3):673-691. doi: 10.1007/s00204-018-2377-7. Epub 2018 Dec 18. Arch Toxicol. 2019. PMID: 30564897
45 results