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Signal strength dictates phosphoinositide 3-kinase contribution to Ras/extracellular signal-regulated kinase 1 and 2 activation via differential Gab1/Shp2 recruitment: consequences for resistance to epidermal growth factor receptor inhibition.
Sampaio C, Dance M, Montagner A, Edouard T, Malet N, Perret B, Yart A, Salles JP, Raynal P. Sampaio C, et al. Among authors: malet n. Mol Cell Biol. 2008 Jan;28(2):587-600. doi: 10.1128/MCB.01318-07. Epub 2007 Nov 19. Mol Cell Biol. 2008. PMID: 18025104 Free PMC article.
Absence of the lysophosphatidic acid receptor LPA1 results in abnormal bone development and decreased bone mass.
Gennero I, Laurencin-Dalicieux S, Conte-Auriol F, Briand-Mésange F, Laurencin D, Rue J, Beton N, Malet N, Mus M, Tokumura A, Bourin P, Vico L, Brunel G, Oreffo RO, Chun J, Salles JP. Gennero I, et al. Among authors: malet n. Bone. 2011 Sep;49(3):395-403. doi: 10.1016/j.bone.2011.04.018. Epub 2011 May 1. Bone. 2011. PMID: 21569876 Free PMC article.
Elastin-derived peptides potentiate atherosclerosis through the immune Neu1-PI3Kγ pathway.
Gayral S, Garnotel R, Castaing-Berthou A, Blaise S, Fougerat A, Berge E, Montheil A, Malet N, Wymann MP, Maurice P, Debelle L, Martiny L, Martinez LO, Pshezhetsky AV, Duca L, Laffargue M. Gayral S, et al. Among authors: malet n. Cardiovasc Res. 2014 Apr 1;102(1):118-27. doi: 10.1093/cvr/cvt336. Epub 2013 Dec 19. Cardiovasc Res. 2014. PMID: 24357053
Targeting PI3Kγ activity decreases vascular trauma-induced intimal hyperplasia through modulation of the Th1 response.
Smirnova NF, Gayral S, Pedros C, Loirand G, Vaillant N, Malet N, Kassem S, Calise D, Goudounèche D, Wymann MP, Hirsch E, Gadeau AP, Martinez LO, Saoudi A, Laffargue M. Smirnova NF, et al. Among authors: malet n. J Exp Med. 2014 Aug 25;211(9):1779-92. doi: 10.1084/jem.20131276. Epub 2014 Jul 29. J Exp Med. 2014. PMID: 25073791 Free PMC article.
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