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Targeting Aggrephagy for the Treatment of Alzheimer's Disease.
Malampati S, Song JX, Chun-Kit Tong B, Nalluri A, Yang CB, Wang Z, Gopalkrishnashetty Sreenivasmurthy S, Zhu Z, Liu J, Su C, Krishnamoorthi S, Iyaswamy A, Cheung KH, Lu JH, Li AM. Malampati S, et al. Cells. 2020 Jan 28;9(2):311. doi: 10.3390/cells9020311. Cells. 2020. PMID: 32012902 Free PMC article. Review.
A small molecule transcription factor EB activator ameliorates beta-amyloid precursor protein and Tau pathology in Alzheimer's disease models.
Song JX, Malampati S, Zeng Y, Durairajan SSK, Yang CB, Tong BC, Iyaswamy A, Shang WB, Sreenivasmurthy SG, Zhu Z, Cheung KH, Lu JH, Tang C, Xu N, Li M. Song JX, et al. Among authors: malampati s. Aging Cell. 2020 Feb;19(2):e13069. doi: 10.1111/acel.13069. Epub 2019 Dec 19. Aging Cell. 2020. PMID: 31858697 Free PMC article.
NeuroDefend, a novel Chinese medicine, attenuates amyloid-β and tau pathology in experimental Alzheimer's disease models.
Iyaswamy A, Krishnamoorthi SK, Song JX, Yang CB, Kaliyamoorthy V, Zhang H, Sreenivasmurthy SG, Malampati S, Wang ZY, Zhu Z, Tong BC, Cheung KH, Lu JH, Durairajan SSK, Li M. Iyaswamy A, et al. Among authors: malampati s. J Food Drug Anal. 2020 Jan;28(1):132-146. doi: 10.1016/j.jfda.2019.09.004. Epub 2019 Oct 8. J Food Drug Anal. 2020. PMID: 31883601 Free article.
Lysosomal TPCN (two pore segment channel) inhibition ameliorates beta-amyloid pathology and mitigates memory impairment in Alzheimer disease.
Tong BC, Wu AJ, Huang AS, Dong R, Malampati S, Iyaswamy A, Krishnamoorthi S, Sreenivasmurthy SG, Zhu Z, Su C, Liu J, Song J, Lu JH, Tan J, Pan W, Li M, Cheung KH. Tong BC, et al. Among authors: malampati s. Autophagy. 2022 Mar;18(3):624-642. doi: 10.1080/15548627.2021.1945220. Epub 2021 Jul 27. Autophagy. 2022. PMID: 34313551 Free PMC article.
Protopine promotes the proteasomal degradation of pathological tau in Alzheimer's disease models via HDAC6 inhibition.
Sreenivasmurthy SG, Iyaswamy A, Krishnamoorthi S, Senapati S, Malampati S, Zhu Z, Su CF, Liu J, Guan XJ, Tong BC, Cheung KH, Tan JQ, Lu JH, Durairajan SSK, Song JX, Li M. Sreenivasmurthy SG, et al. Among authors: malampati s. Phytomedicine. 2022 Feb;96:153887. doi: 10.1016/j.phymed.2021.153887. Epub 2021 Dec 8. Phytomedicine. 2022. PMID: 34936968
Yuan-Hu Zhi Tong Prescription Mitigates Tau Pathology and Alleviates Memory Deficiency in the Preclinical Models of Alzheimer's Disease.
Iyaswamy A, Krishnamoorthi SK, Liu YW, Song JX, Kammala AK, Sreenivasmurthy SG, Malampati S, Tong BCK, Selvarasu K, Cheung KH, Lu JH, Tan JQ, Huang CY, Durairajan SSK, Li M. Iyaswamy A, et al. Among authors: malampati s. Front Pharmacol. 2020 Oct 30;11:584770. doi: 10.3389/fphar.2020.584770. eCollection 2020. Front Pharmacol. 2020. PMID: 33192524 Free PMC article. Review.
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