Makishima M - Search Results

1

RXR partial agonist produced by side chain repositioning of alkoxy RXR full agonist retains antitype 2 diabetes activity without the adverse effects.

Kawata K, Morishita K, Nakayama M, Yamada S, Kobayashi T, Furusawa Y, Arimoto-Kobayashi S, Oohashi T, Makishima M, Naitou H, Ishitsubo E, Tokiwa H, Tai A, Kakuta H. Kawata K, et al. Among authors: makishima m. J Med Chem. 2015 Jan 22;58(2):912-26. doi: 10.1021/jm501863r. Epub 2014 Dec 17. J Med Chem. 2015. PMID: 25486327

2

Design and synthesis of substituted phenylpropanoic acid derivatives as human peroxisome proliferator-activated receptor alpha/delta dual agonists.

Kasuga J, Makishima M, Hashimoto Y, Miyachi H. Kasuga J, et al. Among authors: makishima m. Bioorg Med Chem Lett. 2006 Feb;16(3):554-8. doi: 10.1016/j.bmcl.2005.10.049. Epub 2005 Nov 3. Bioorg Med Chem Lett. 2006. PMID: 16275077

3

Vitamin D receptor: ligand recognition and allosteric network.

Yamamoto K, Abe D, Yoshimoto N, Choi M, Yamagishi K, Tokiwa H, Shimizu M, Makishima M, Yamada S. Yamamoto K, et al. Among authors: makishima m. J Med Chem. 2006 Feb 23;49(4):1313-24. doi: 10.1021/jm050795q. J Med Chem. 2006. PMID: 16480267

4

Reduction of lipophilicity at the lipophilic domain of RXR agonists enables production of subtype preference: RXRalpha-preferential agonist possessing a sulfonamide moiety.

Takamatsu K, Takano A, Yakushiji N, Morishita K, Matsuura N, Makishima M, Ali HI, Akaho E, Tai A, Sasaki K, Kakuta H. Takamatsu K, et al. Among authors: makishima m. ChemMedChem. 2008 Mar;3(3):454-60. doi: 10.1002/cmdc.200700265. ChemMedChem. 2008. PMID: 18157857

5

The first potent subtype-selective retinoid X receptor (RXR) agonist possessing a 3-isopropoxy-4-isopropylphenylamino moiety, NEt-3IP (RXRalpha/beta-dual agonist).

Takamatsu K, Takano A, Yakushiji N, Morohashi K, Morishita K, Matsuura N, Makishima M, Tai A, Sasaki K, Kakuta H. Takamatsu K, et al. Among authors: makishima m. ChemMedChem. 2008 May;3(5):780-7. doi: 10.1002/cmdc.200700313. ChemMedChem. 2008. PMID: 18297677

6

Crystal structures of rat vitamin D receptor bound to adamantyl vitamin D analogs: structural basis for vitamin D receptor antagonism and partial agonism.

Nakabayashi M, Yamada S, Yoshimoto N, Tanaka T, Igarashi M, Ikura T, Ito N, Makishima M, Tokiwa H, DeLuca HF, Shimizu M. Nakabayashi M, et al. Among authors: makishima m. J Med Chem. 2008 Sep 11;51(17):5320-9. doi: 10.1021/jm8004477. Epub 2008 Aug 19. J Med Chem. 2008. PMID: 18710208

7

Identification of G protein-coupled receptor 120-selective agonists derived from PPARgamma agonists.

Suzuki T, Igari S, Hirasawa A, Hata M, Ishiguro M, Fujieda H, Itoh Y, Hirano T, Nakagawa H, Ogura M, Makishima M, Tsujimoto G, Miyata N. Suzuki T, et al. Among authors: makishima m. J Med Chem. 2008 Dec 11;51(23):7640-4. doi: 10.1021/jm800970b. J Med Chem. 2008. PMID: 19007110

8

Replacing alkyl sulfonamide with aromatic sulfonamide in sulfonamide-type RXR agonists favors switch towards antagonist activity.

Morishita K, Yakushiji N, Ohsawa F, Takamatsu K, Matsuura N, Makishima M, Kawahata M, Yamaguchi K, Tai A, Sasaki K, Kakuta H. Morishita K, et al. Among authors: makishima m. Bioorg Med Chem Lett. 2009 Feb 1;19(3):1001-3. doi: 10.1016/j.bmcl.2008.11.086. Epub 2008 Nov 27. Bioorg Med Chem Lett. 2009. PMID: 19095448

9

Interactions between 1alpha,25(OH)2D3 and residues in the ligand-binding pocket of the vitamin D receptor: a correlated fragment molecular orbital study.

Yamagishi K, Tokiwa H, Makishima M, Yamada S. Yamagishi K, et al. Among authors: makishima m. J Steroid Biochem Mol Biol. 2010 Jul;121(1-2):63-7. doi: 10.1016/j.jsbmb.2010.03.028. Epub 2010 Mar 15. J Steroid Biochem Mol Biol. 2010. PMID: 20236613

10

Modification at the acidic domain of RXR agonists has little effect on permissive RXR-heterodimer activation.

Fujii S, Ohsawa F, Yamada S, Shinozaki R, Fukai R, Makishima M, Enomoto S, Tai A, Kakuta H. Fujii S, et al. Among authors: makishima m. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5139-42. doi: 10.1016/j.bmcl.2010.07.012. Epub 2010 Jul 8. Bioorg Med Chem Lett. 2010. PMID: 20656484

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