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The DREAM complex mediates GIST cell quiescence and is a novel therapeutic target to enhance imatinib-induced apoptosis.
Boichuk S, Parry JA, Makielski KR, Litovchick L, Baron JL, Zewe JP, Wozniak A, Mehalek KR, Korzeniewski N, Seneviratne DS, Schöffski P, Debiec-Rychter M, DeCaprio JA, Duensing A. Boichuk S, et al. Among authors: makielski kr. Cancer Res. 2013 Aug 15;73(16):5120-9. doi: 10.1158/0008-5472.CAN-13-0579. Epub 2013 Jun 20. Cancer Res. 2013. PMID: 23786773
Unbiased compound screening identifies unexpected drug sensitivities and novel treatment options for gastrointestinal stromal tumors.
Boichuk S, Lee DJ, Mehalek KR, Makielski KR, Wozniak A, Seneviratne DS, Korzeniewski N, Cuevas R, Parry JA, Brown MF, Zewe J, Taguchi T, Kuan SF, Schöffski P, Debiec-Rychter M, Duensing A. Boichuk S, et al. Among authors: makielski kr. Cancer Res. 2014 Feb 15;74(4):1200-13. doi: 10.1158/0008-5472.CAN-13-1955. Epub 2014 Jan 2. Cancer Res. 2014. PMID: 24385214
Differential antitumor activity of compounds targeting the ubiquitin-proteasome machinery in gastrointestinal stromal tumor (GIST) cells.
Rausch JL, Ali AA, Lee DM, Gebreyohannes YK, Mehalek KR, Agha A, Patil SS, Tolstov Y, Wellens J, Dhillon HS, Makielski KR, Debiec-Rychter M, Schöffski P, Wozniak A, Duensing A. Rausch JL, et al. Among authors: makielski kr. Sci Rep. 2020 Mar 20;10(1):5178. doi: 10.1038/s41598-020-62088-7. Sci Rep. 2020. PMID: 32198455 Free PMC article.
ΔNp63α promotes Epstein-Barr virus latency in undifferentiated epithelial cells.
Van Sciver N, Ohashi M, Nawandar DM, Pauly NP, Lee D, Makielski KR, Bristol JA, Tsao SW, Lambert PF, Johannsen EC, Kenney SC. Van Sciver N, et al. Among authors: makielski kr. PLoS Pathog. 2021 Nov 8;17(11):e1010045. doi: 10.1371/journal.ppat.1010045. eCollection 2021 Nov. PLoS Pathog. 2021. PMID: 34748616 Free PMC article.
Hypoxia-inducible factor-1α plays roles in Epstein-Barr virus's natural life cycle and tumorigenesis by inducing lytic infection through direct binding to the immediate-early BZLF1 gene promoter.
Kraus RJ, Yu X, Cordes BA, Sathiamoorthi S, Iempridee T, Nawandar DM, Ma S, Romero-Masters JC, McChesney KG, Lin Z, Makielski KR, Lee DL, Lambert PF, Johannsen EC, Kenney SC, Mertz JE. Kraus RJ, et al. Among authors: makielski kr. PLoS Pathog. 2017 Jun 15;13(6):e1006404. doi: 10.1371/journal.ppat.1006404. eCollection 2017 Jun. PLoS Pathog. 2017. PMID: 28617871 Free PMC article.
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