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In Silico Fragment-Based Design Identifies Subfamily B1 Metallo-β-lactamase Inhibitors.
J Med Chem. 2018 Feb 8;61(3):1255-1260. doi: 10.1021/acs.jmedchem.7b01728. Epub 2018 Jan 10.
J Med Chem. 2018.
PMID: 29271657
Free article.
Chromophore-linked substrate (CLS405): probing metallo-β-lactamase activity and inhibition.
Makena A, van Berkel SS, Lejeune C, Owens RJ, Verma A, Salimraj R, Spencer J, Brem J, Schofield CJ.
Makena A, et al.
ChemMedChem. 2013 Dec;8(12):1923-9. doi: 10.1002/cmdc.201300350. Epub 2013 Oct 25.
ChemMedChem. 2013.
PMID: 24166830
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Monitoring conformational changes in the NDM-1 metallo-β-lactamase by 19F NMR spectroscopy.
Rydzik AM, Brem J, van Berkel SS, Pfeffer I, Makena A, Claridge TD, Schofield CJ.
Rydzik AM, et al. Among authors: makena a.
Angew Chem Int Ed Engl. 2014 Mar 17;53(12):3129-33. doi: 10.1002/anie.201310866. Epub 2014 Feb 24.
Angew Chem Int Ed Engl. 2014.
PMID: 24615874
Free PMC article.
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Biochemical characterization of New Delhi metallo-β-lactamase variants reveals differences in protein stability.
Makena A, Brem J, Pfeffer I, Geffen RE, Wilkins SE, Tarhonskaya H, Flashman E, Phee LM, Wareham DW, Schofield CJ.
Makena A, et al.
J Antimicrob Chemother. 2015 Feb;70(2):463-9. doi: 10.1093/jac/dku403. Epub 2014 Oct 16.
J Antimicrob Chemother. 2015.
PMID: 25324420
Free PMC article.
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19 F-NMR Reveals the Role of Mobile Loops in Product and Inhibitor Binding by the São Paulo Metallo-β-Lactamase.
Abboud MI, Hinchliffe P, Brem J, Macsics R, Pfeffer I, Makena A, Umland KD, Rydzik AM, Li GB, Spencer J, Claridge TD, Schofield CJ.
Abboud MI, et al. Among authors: makena a.
Angew Chem Int Ed Engl. 2017 Mar 27;56(14):3862-3866. doi: 10.1002/anie.201612185. Epub 2017 Mar 2.
Angew Chem Int Ed Engl. 2017.
PMID: 28252254
Free PMC article.
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Comparison of Verona Integron-Borne Metallo-β-Lactamase (VIM) Variants Reveals Differences in Stability and Inhibition Profiles.
Makena A, Düzgün AÖ, Brem J, McDonough MA, Rydzik AM, Abboud MI, Saral A, Çiçek AÇ, Sandalli C, Schofield CJ.
Makena A, et al.
Antimicrob Agents Chemother. 2015 Dec 14;60(3):1377-84. doi: 10.1128/AAC.01768-15.
Antimicrob Agents Chemother. 2015.
PMID: 26666919
Free PMC article.
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