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NAD+ bioavailability mediates PARG inhibition-induced replication arrest, intra S-phase checkpoint and apoptosis in glioma stem cells.
Li J, M Saville K, Ibrahim M, Zeng X, McClellan S, Angajala A, Beiser A, Andrews JF, Sun M, Koczor CA, Clark J, Hayat F, Makarov MV, Wilk A, Yates NA, Migaud ME, Sobol RW. Li J, et al. Among authors: makarov mv. NAR Cancer. 2021 Nov 17;3(4):zcab044. doi: 10.1093/narcan/zcab044. eCollection 2021 Dec. NAR Cancer. 2021. PMID: 34806016 Free PMC article.
The chemistry of the vitamin B3 metabolome.
Makarov MV, Trammell SAJ, Migaud ME. Makarov MV, et al. Biochem Soc Trans. 2019 Feb 28;47(1):131-147. doi: 10.1042/BST20180420. Epub 2018 Dec 17. Biochem Soc Trans. 2019. PMID: 30559273 Free PMC article. Review.
Scalable syntheses of traceable ribosylated NAD+ precursors.
Makarov MV, Harris NW, Rodrigues M, Migaud ME. Makarov MV, et al. Org Biomol Chem. 2019 Oct 14;17(38):8716-8720. doi: 10.1039/c9ob01981b. Epub 2019 Sep 20. Org Biomol Chem. 2019. PMID: 31538639 Free PMC article.
A reduced form of nicotinamide riboside defines a new path for NAD+ biosynthesis and acts as an orally bioavailable NAD+ precursor.
Giroud-Gerbetant J, Joffraud M, Giner MP, Cercillieux A, Bartova S, Makarov MV, Zapata-Pérez R, Sánchez-García JL, Houtkooper RH, Migaud ME, Moco S, Canto C. Giroud-Gerbetant J, et al. Among authors: makarov mv. Mol Metab. 2019 Dec;30:192-202. doi: 10.1016/j.molmet.2019.09.013. Epub 2019 Oct 3. Mol Metab. 2019. PMID: 31767171 Free PMC article.
Bacteria Boost Mammalian Host NAD Metabolism by Engaging the Deamidated Biosynthesis Pathway.
Shats I, Williams JG, Liu J, Makarov MV, Wu X, Lih FB, Deterding LJ, Lim C, Xu X, Randall TA, Lee E, Li W, Fan W, Li JL, Sokolsky M, Kabanov AV, Li L, Migaud ME, Locasale JW, Li X. Shats I, et al. Among authors: makarov mv. Cell Metab. 2020 Mar 3;31(3):564-579.e7. doi: 10.1016/j.cmet.2020.02.001. Cell Metab. 2020. PMID: 32130883 Free PMC article.
The Biochemical Pathways of Nicotinamide-Derived Pyridones.
Hayat F, Sonavane M, Makarov MV, Trammell SAJ, McPherson P, Gassman NR, Migaud ME. Hayat F, et al. Among authors: makarov mv. Int J Mol Sci. 2021 Jan 24;22(3):1145. doi: 10.3390/ijms22031145. Int J Mol Sci. 2021. PMID: 33498933 Free PMC article.
Discovery of fungal surface NADases predominantly present in pathogenic species.
Strømland Ø, Kallio JP, Pschibul A, Skoge RH, Harðardóttir HM, Sverkeli LJ, Heinekamp T, Kniemeyer O, Migaud M, Makarov MV, Gossmann TI, Brakhage AA, Ziegler M. Strømland Ø, et al. Among authors: makarov mv. Nat Commun. 2021 Mar 12;12(1):1631. doi: 10.1038/s41467-021-21307-z. Nat Commun. 2021. PMID: 33712585 Free PMC article.
28 results