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N-domain of angiotensin-converting enzyme hydrolyzes human and rat amyloid-β(1-16) peptides as arginine specific endopeptidase potentially enhancing risk of Alzheimer's disease.
Kugaevskaya EV, Veselovsky AV, Indeykina MI, Solovyeva NI, Zharkova MS, Popov IA, Nikolaev EN, Mantsyzov AB, Makarov AA, Kozin SA. Kugaevskaya EV, et al. Among authors: makarov aa. Sci Rep. 2018 Jan 10;8(1):298. doi: 10.1038/s41598-017-18567-5. Sci Rep. 2018. PMID: 29321566 Free PMC article.
The N-domain of angiotensin-converting enzyme specifically hydrolyzes the Arg-5-His-6 bond of Alzheimer's Abeta-(1-16) peptide and its isoAsp-7 analogue with different efficiency as evidenced by quantitative matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.
Toropygin IY, Kugaevskaya EV, Mirgorodskaya OA, Elisseeva YE, Kozmin YP, Popov IA, Nikolaev EN, Makarov AA, Kozin SA. Toropygin IY, et al. Among authors: makarov aa. Rapid Commun Mass Spectrom. 2008;22(2):231-9. doi: 10.1002/rcm.3357. Rapid Commun Mass Spectrom. 2008. PMID: 18085519
Minimal Zn(2+) binding site of amyloid-β.
Tsvetkov PO, Kulikova AA, Golovin AV, Tkachev YV, Archakov AI, Kozin SA, Makarov AA. Tsvetkov PO, et al. Among authors: makarov aa. Biophys J. 2010 Nov 17;99(10):L84-6. doi: 10.1016/j.bpj.2010.09.015. Biophys J. 2010. PMID: 21081056 Free PMC article.
361 results