Major MB - Search Results

1

STING Suppresses Mitochondrial VDAC2 to Govern RCC Growth Independent of Innate Immunity.

Zhu Z, Zhou X, Du H, Cloer EW, Zhang J, Mei L, Wang Y, Tan X, Hepperla AJ, Simon JM, Cook JG, Major MB, Dotti G, Liu P. Zhu Z, et al. Among authors: major mb. Adv Sci (Weinh). 2023 Jan;10(3):e2203718. doi: 10.1002/advs.202203718. Epub 2022 Nov 29. Adv Sci (Weinh). 2023. PMID: 36445063 Free PMC article.

2

Cancer-derived mutations in KEAP1 impair NRF2 degradation but not ubiquitination.

Hast BE, Cloer EW, Goldfarb D, Li H, Siesser PF, Yan F, Walter V, Zheng N, Hayes DN, Major MB. Hast BE, et al. Among authors: major mb. Cancer Res. 2014 Feb 1;74(3):808-17. doi: 10.1158/0008-5472.CAN-13-1655. Epub 2013 Dec 9. Cancer Res. 2014. PMID: 24322982 Free PMC article.

3

BRG1/SMARCA4 inactivation promotes non-small cell lung cancer aggressiveness by altering chromatin organization.

Orvis T, Hepperla A, Walter V, Song S, Simon J, Parker J, Wilkerson MD, Desai N, Major MB, Hayes DN, Davis IJ, Weissman B. Orvis T, et al. Among authors: major mb. Cancer Res. 2014 Nov 15;74(22):6486-6498. doi: 10.1158/0008-5472.CAN-14-0061. Epub 2014 Aug 12. Cancer Res. 2014. PMID: 25115300 Free PMC article.

4

Engineering a genetically encoded competitive inhibitor of the KEAP1-NRF2 interaction via structure-based design and phage display.

Guntas G, Lewis SM, Mulvaney KM, Cloer EW, Tripathy A, Lane TR, Major MB, Kuhlman B. Guntas G, et al. Among authors: major mb. Protein Eng Des Sel. 2016 Jan;29(1):1-9. doi: 10.1093/protein/gzv055. Epub 2015 Oct 20. Protein Eng Des Sel. 2016. PMID: 26489878 Free PMC article.

5

Identification and Characterization of MCM3 as a Kelch-like ECH-associated Protein 1 (KEAP1) Substrate.

Mulvaney KM, Matson JP, Siesser PF, Tamir TY, Goldfarb D, Jacobs TM, Cloer EW, Harrison JS, Vaziri C, Cook JG, Major MB. Mulvaney KM, et al. Among authors: major mb. J Biol Chem. 2016 Nov 4;291(45):23719-23733. doi: 10.1074/jbc.M116.729418. Epub 2016 Sep 12. J Biol Chem. 2016. PMID: 27621311 Free PMC article.

6

p62-Dependent Phase Separation of Patient-Derived KEAP1 Mutations and NRF2.

Cloer EW, Siesser PF, Cousins EM, Goldfarb D, Mowrey DD, Harrison JS, Weir SJ, Dokholyan NV, Major MB. Cloer EW, et al. Among authors: major mb. Mol Cell Biol. 2018 Oct 29;38(22):e00644-17. doi: 10.1128/MCB.00644-17. Print 2018 Nov 15. Mol Cell Biol. 2018. PMID: 30126895 Free PMC article.

7

NRF2 Activation in Cancer: From DNA to Protein.

Cloer EW, Goldfarb D, Schrank TP, Weissman BE, Major MB. Cloer EW, et al. Among authors: major mb. Cancer Res. 2019 Mar 1;79(5):889-898. doi: 10.1158/0008-5472.CAN-18-2723. Epub 2019 Feb 13. Cancer Res. 2019. PMID: 30760522 Free PMC article. Review.

8

A conditional mouse expressing an activating mutation in NRF2 displays hyperplasia of the upper gastrointestinal tract and decreased white adipose tissue.

Bowman BM, Montgomery SA, Schrank TP, Simon JM, Ptacek TS, Tamir TY, Mulvaney KM, Weir SJ, Nguyen TT, Murphy RM, Makowski L, Hayes DN, Chen XL, Randell SH, Weissman BE, Major MB. Bowman BM, et al. Among authors: major mb. J Pathol. 2020 Oct;252(2):125-137. doi: 10.1002/path.5504. Epub 2020 Aug 29. J Pathol. 2020. PMID: 32619021 Free PMC article.

9

Comprehensive nucleosome interactome screen establishes fundamental principles of nucleosome binding.

Skrajna A, Goldfarb D, Kedziora KM, Cousins EM, Grant GD, Spangler CJ, Barbour EH, Yan X, Hathaway NA, Brown NG, Cook JG, Major MB, McGinty RK. Skrajna A, et al. Among authors: major mb. Nucleic Acids Res. 2020 Sep 25;48(17):9415-9432. doi: 10.1093/nar/gkaa544. Nucleic Acids Res. 2020. PMID: 32658293 Free PMC article.

10

The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis.

Menon S, Goldfarb D, Ho CT, Cloer EW, Boyer NP, Hardie C, Bock AJ, Johnson EC, Anil J, Major MB, Gupton SL. Menon S, et al. Among authors: major mb. Mol Biol Cell. 2021 Feb 15;32(4):314-330. doi: 10.1091/mbc.E20-10-0622. Epub 2020 Dec 30. Mol Biol Cell. 2021. PMID: 33378226 Free PMC article.

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