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α-Synuclein aggregation nucleates through liquid-liquid phase separation.
Ray S, Singh N, Kumar R, Patel K, Pandey S, Datta D, Mahato J, Panigrahi R, Navalkar A, Mehra S, Gadhe L, Chatterjee D, Sawner AS, Maiti S, Bhatia S, Gerez JA, Chowdhury A, Kumar A, Padinhateeri R, Riek R, Krishnamoorthy G, Maji SK. Ray S, et al. Among authors: maji sk. Nat Chem. 2020 Aug;12(8):705-716. doi: 10.1038/s41557-020-0465-9. Epub 2020 Jun 8. Nat Chem. 2020. PMID: 32514159
The fold of alpha-synuclein fibrils.
Vilar M, Chou HT, Lührs T, Maji SK, Riek-Loher D, Verel R, Manning G, Stahlberg H, Riek R. Vilar M, et al. Among authors: maji sk. Proc Natl Acad Sci U S A. 2008 Jun 24;105(25):8637-42. doi: 10.1073/pnas.0712179105. Epub 2008 Jun 12. Proc Natl Acad Sci U S A. 2008. PMID: 18550842 Free PMC article.
Structure-activity relationship of amyloid fibrils.
Maji SK, Wang L, Greenwald J, Riek R. Maji SK, et al. FEBS Lett. 2009 Aug 20;583(16):2610-7. doi: 10.1016/j.febslet.2009.07.003. Epub 2009 Jul 14. FEBS Lett. 2009. PMID: 19596006 Free article. Review.
In vivo demonstration that alpha-synuclein oligomers are toxic.
Winner B, Jappelli R, Maji SK, Desplats PA, Boyer L, Aigner S, Hetzer C, Loher T, Vilar M, Campioni S, Tzitzilonis C, Soragni A, Jessberger S, Mira H, Consiglio A, Pham E, Masliah E, Gage FH, Riek R. Winner B, et al. Among authors: maji sk. Proc Natl Acad Sci U S A. 2011 Mar 8;108(10):4194-9. doi: 10.1073/pnas.1100976108. Epub 2011 Feb 15. Proc Natl Acad Sci U S A. 2011. PMID: 21325059 Free PMC article.
Curcumin modulates α-synuclein aggregation and toxicity.
Singh PK, Kotia V, Ghosh D, Mohite GM, Kumar A, Maji SK. Singh PK, et al. Among authors: maji sk. ACS Chem Neurosci. 2013 Mar 20;4(3):393-407. doi: 10.1021/cn3001203. Epub 2012 Dec 17. ACS Chem Neurosci. 2013. PMID: 23509976 Free PMC article.
Elucidating the role of disulfide bond on amyloid formation and fibril reversibility of somatostatin-14: relevance to its storage and secretion.
Anoop A, Ranganathan S, Das Dhaked B, Jha NN, Pratihar S, Ghosh S, Sahay S, Kumar S, Das S, Kombrabail M, Agarwal K, Jacob RS, Singru P, Bhaumik P, Padinhateeri R, Kumar A, Maji SK. Anoop A, et al. Among authors: maji sk. J Biol Chem. 2014 Jun 13;289(24):16884-903. doi: 10.1074/jbc.M114.548354. Epub 2014 Apr 29. J Biol Chem. 2014. PMID: 24782311 Free PMC article.
135 results