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Interaction between hormone-sensitive lipase and ChREBP in fat cells controls insulin sensitivity.
Morigny P, Houssier M, Mairal A, Ghilain C, Mouisel E, Benhamed F, Masri B, Recazens E, Denechaud PD, Tavernier G, Caspar-Bauguil S, Virtue S, Sramkova V, Monbrun L, Mazars A, Zanoun M, Guilmeau S, Barquissau V, Beuzelin D, Bonnel S, Marques M, Monge-Roffarello B, Lefort C, Fielding B, Sulpice T, Astrup A, Payrastre B, Bertrand-Michel J, Meugnier E, Ligat L, Lopez F, Guillou H, Ling C, Holm C, Rabasa-Lhoret R, Saris WHM, Stich V, Arner P, Rydén M, Moro C, Viguerie N, Harms M, Hallén S, Vidal-Puig A, Vidal H, Postic C, Langin D. Morigny P, et al. Among authors: mairal a. Nat Metab. 2019 Jan;1(1):133-146. doi: 10.1038/s42255-018-0007-6. Epub 2018 Dec 3. Nat Metab. 2019. PMID: 32694809
Partial inhibition of adipose tissue lipolysis improves glucose metabolism and insulin sensitivity without alteration of fat mass.
Girousse A, Tavernier G, Valle C, Moro C, Mejhert N, Dinel AL, Houssier M, Roussel B, Besse-Patin A, Combes M, Mir L, Monbrun L, Bézaire V, Prunet-Marcassus B, Waget A, Vila I, Caspar-Bauguil S, Louche K, Marques MA, Mairal A, Renoud ML, Galitzky J, Holm C, Mouisel E, Thalamas C, Viguerie N, Sulpice T, Burcelin R, Arner P, Langin D. Girousse A, et al. Among authors: mairal a. PLoS Biol. 2013;11(2):e1001485. doi: 10.1371/journal.pbio.1001485. Epub 2013 Feb 19. PLoS Biol. 2013. PMID: 23431266 Free PMC article. Clinical Trial.
Hormone-sensitive lipase is a cholesterol esterase of the intestinal mucosa.
Grober J, Lucas S, Sörhede-Winzell M, Zaghini I, Mairal A, Contreras JA, Besnard P, Holm C, Langin D. Grober J, et al. Among authors: mairal a. J Biol Chem. 2003 Feb 21;278(8):6510-5. doi: 10.1074/jbc.M208513200. Epub 2002 Dec 13. J Biol Chem. 2003. PMID: 12482847 Free article.
Adipocyte lipases and defect of lipolysis in human obesity.
Langin D, Dicker A, Tavernier G, Hoffstedt J, Mairal A, Rydén M, Arner E, Sicard A, Jenkins CM, Viguerie N, van Harmelen V, Gross RW, Holm C, Arner P. Langin D, et al. Among authors: mairal a. Diabetes. 2005 Nov;54(11):3190-7. doi: 10.2337/diabetes.54.11.3190. Diabetes. 2005. PMID: 16249444
Skeletal muscle lipase content and activity in obesity and type 2 diabetes.
Jocken JW, Moro C, Goossens GH, Hansen D, Mairal A, Hesselink MK, Langin D, van Loon LJ, Blaak EE. Jocken JW, et al. Among authors: mairal a. J Clin Endocrinol Metab. 2010 Dec;95(12):5449-53. doi: 10.1210/jc.2010-0776. Epub 2010 Sep 15. J Clin Endocrinol Metab. 2010. PMID: 20843949
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