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Diverse alterations associated with resistance to KRAS(G12C) inhibition.
Zhao Y, Murciano-Goroff YR, Xue JY, Ang A, Lucas J, Mai TT, Da Cruz Paula AF, Saiki AY, Mohn D, Achanta P, Sisk AE, Arora KS, Roy RS, Kim D, Li C, Lim LP, Li M, Bahr A, Loomis BR, de Stanchina E, Reis-Filho JS, Weigelt B, Berger M, Riely G, Arbour KC, Lipford JR, Li BT, Lito P. Zhao Y, et al. Among authors: mai tt. Nature. 2021 Nov;599(7886):679-683. doi: 10.1038/s41586-021-04065-2. Epub 2021 Nov 10. Nature. 2021. PMID: 34759319 Free PMC article.
A treatment strategy for KRAS-driven tumors.
Mai TT, Lito P. Mai TT, et al. Nat Med. 2018 Jul;24(7):902-904. doi: 10.1038/s41591-018-0111-x. Nat Med. 2018. PMID: 29988139 No abstract available.
Rapid non-uniform adaptation to conformation-specific KRAS(G12C) inhibition.
Xue JY, Zhao Y, Aronowitz J, Mai TT, Vides A, Qeriqi B, Kim D, Li C, de Stanchina E, Mazutis L, Risso D, Lito P. Xue JY, et al. Among authors: mai tt. Nature. 2020 Jan;577(7790):421-425. doi: 10.1038/s41586-019-1884-x. Epub 2020 Jan 8. Nature. 2020. PMID: 31915379 Free PMC article.
An approach to suppress the evolution of resistance in BRAFV600E-mutant cancer.
Xue Y, Martelotto L, Baslan T, Vides A, Solomon M, Mai TT, Chaudhary N, Riely GJ, Li BT, Scott K, Cechhi F, Stierner U, Chadalavada K, de Stanchina E, Schwartz S, Hembrough T, Nanjangud G, Berger MF, Nilsson J, Lowe SW, Reis-Filho JS, Rosen N, Lito P. Xue Y, et al. Among authors: mai tt. Nat Med. 2017 Aug;23(8):929-937. doi: 10.1038/nm.4369. Epub 2017 Jul 17. Nat Med. 2017. PMID: 28714990 Free PMC article.
Salinomycin kills cancer stem cells by sequestering iron in lysosomes.
Mai TT, Hamaï A, Hienzsch A, Cañeque T, Müller S, Wicinski J, Cabaud O, Leroy C, David A, Acevedo V, Ryo A, Ginestier C, Birnbaum D, Charafe-Jauffret E, Codogno P, Mehrpour M, Rodriguez R. Mai TT, et al. Nat Chem. 2017 Oct;9(10):1025-1033. doi: 10.1038/nchem.2778. Epub 2017 May 16. Nat Chem. 2017. PMID: 28937680 Free PMC article.
An iron hand over cancer stem cells.
Hamaï A, Cañeque T, Müller S, Mai TT, Hienzsch A, Ginestier C, Charafe-Jauffret E, Codogno P, Mehrpour M, Rodriguez R. Hamaï A, et al. Among authors: mai tt. Autophagy. 2017 Aug 3;13(8):1465-1466. doi: 10.1080/15548627.2017.1327104. Epub 2017 Jun 14. Autophagy. 2017. PMID: 28613094 Free PMC article.
Quorum sensing inhibitors from Leucetta chagosensis Dendy, 1863.
Mai T, Tintillier F, Lucasson A, Moriou C, Bonno E, Petek S, Magré K, Al Mourabit A, Saulnier D, Debitus C. Mai T, et al. Lett Appl Microbiol. 2015 Oct;61(4):311-7. doi: 10.1111/lam.12461. Epub 2015 Aug 14. Lett Appl Microbiol. 2015. PMID: 26138555
Discovery of GLPG2737, a Potent Type 2 Corrector of CFTR for the Treatment of Cystic Fibrosis in Combination with a Potentiator and a Type 1 Co-corrector.
Pizzonero M, Akkari R, Bock X, Gosmini R, De Lemos E, Duthion B, Newsome G, Mai TT, Roques V, Jary H, Lefrancois JM, Cherel L, Quenehen V, Babel M, Merayo N, Bienvenu N, Mammoliti O, Coti G, Palisse A, Cowart M, Shrestha A, Greszler S, Van Der Plas S, Jansen K, Claes P, Jans M, Gees M, Borgonovi M, De Wilde G, Conrath K. Pizzonero M, et al. Among authors: mai tt. J Med Chem. 2024 Apr 11;67(7):5216-5232. doi: 10.1021/acs.jmedchem.3c01790. Epub 2024 Mar 25. J Med Chem. 2024. PMID: 38527911 Free PMC article.
130 results