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Allometric issues in drug development.
Mahmood I. Mahmood I. J Pharm Sci. 1999 Nov;88(11):1101-6. doi: 10.1021/js9902163. J Pharm Sci. 1999. PMID: 10564055 Review.
Interspecies scaling: is a priori knowledge of cytochrome p450 isozymes involved in drug metabolism helpful in prediction of clearance in humans from animal data?
Mahmood I. Mahmood I. Drug Metabol Drug Interact. 2001;18(2):135-47. doi: 10.1515/dmdi.2001.18.2.135. Drug Metabol Drug Interact. 2001. PMID: 11460876
The objective of this study was to evaluate whether a priori knowledge of cytochrome P450 isozymes involved in drug metabolism coupled with Mahmood' and Balian's 'rule of exponents' can be helpful for the prediction of clearance in humans using animal data. ...The choice o …
The objective of this study was to evaluate whether a priori knowledge of cytochrome P450 isozymes involved in drug metabolism coupled with …
241 results