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Transcription of the NKG2D ligand MICA is suppressed by the IRE1/XBP1 pathway of the unfolded protein response through the regulation of E2F1.
Obiedat A, Seidel E, Mahameed M, Berhani O, Tsukerman P, Voutetakis K, Chatziioannou A, McMahon M, Avril T, Chevet E, Mandelboim O, Tirosh B. Obiedat A, et al. Among authors: mahameed m. FASEB J. 2019 Mar;33(3):3481-3495. doi: 10.1096/fj.201801350RR. Epub 2018 Nov 19. FASEB J. 2019. PMID: 30452881
Because of the importance of E2F1 and MICA in cancer progression and recognition, these observations could be exploited for cancer therapy by manipulating the UPR in tumor cells.-Obiedat, A., Seidel, E., Mahameed, M., Berhani, O., Tsukerman, P., Voutetakis, K., Chat …
Because of the importance of E2F1 and MICA in cancer progression and recognition, these observations could be exploited for cancer therapy b …
Cathepsin L Regulates Metabolic Networks Controlling Rapid Cell Growth and Proliferation.
Weiss-Sadan T, Itzhak G, Kaschani F, Yu Z, Mahameed M, Anaki A, Ben-Nun Y, Merquiol E, Tirosh B, Kessler B, Kaiser M, Blum G. Weiss-Sadan T, et al. Among authors: mahameed m. Mol Cell Proteomics. 2019 Jul;18(7):1330-1344. doi: 10.1074/mcp.RA119.001392. Epub 2019 Apr 22. Mol Cell Proteomics. 2019. PMID: 31010818 Free PMC article.
The integrated stress response promotes B7H6 expression.
Obiedat A, Charpak-Amikam Y, Tai-Schmiedel J, Seidel E, Mahameed M, Avril T, Stern-Ginossar N, Springuel L, Bolsée J, Gilham DE, Dipta P, Shmuel M, Chevet E, Mandelboim O, Tirosh B. Obiedat A, et al. Among authors: mahameed m. J Mol Med (Berl). 2020 Jan;98(1):135-148. doi: 10.1007/s00109-019-01859-w. Epub 2019 Dec 14. J Mol Med (Berl). 2020. PMID: 31838577 Free PMC article.
[No title available]
[No authors listed] [No authors listed] PMID: 33451519
19 results