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Elimination of oncogenic KRAS in genetic mouse models eradicates pancreatic cancer by inducing FAS-dependent apoptosis by CD8+ T cells.
Mahadevan KK, LeBleu VS, Ramirez EV, Chen Y, Li B, Sockwell AM, Gagea M, Sugimoto H, Sthanam LK, Tampe D, Zeisberg M, Ying H, Jain AK, DePinho RA, Maitra A, McAndrews KM, Kalluri R. Mahadevan KK, et al. Dev Cell. 2023 Sep 11;58(17):1562-1577.e8. doi: 10.1016/j.devcel.2023.07.025. Epub 2023 Aug 24. Dev Cell. 2023. PMID: 37625403
Oncogenic Kras G12D specific non-covalent inhibitor reprograms tumor microenvironment to prevent and reverse early pre-neoplastic pancreatic lesions and in combination with immunotherapy regresses advanced PDAC in a CD8 + T cells dependent manner.
Mahadevan KK, McAndrews KM, LeBleu VS, Yang S, Lyu H, Li B, Sockwell AM, Kirtley ML, Morse SJ, Moreno Diaz BA, Kim MP, Feng N, Lopez AM, Guerrero PA, Sugimoto H, Arian KA, Ying H, Barekatain Y, Kelly PJ, Maitra A, Heffernan TP, Kalluri R. Mahadevan KK, et al. bioRxiv [Preprint]. 2023 Feb 18:2023.02.15.528757. doi: 10.1101/2023.02.15.528757. bioRxiv. 2023. PMID: 36824971 Free PMC article. Preprint.
KRASG12D inhibition reprograms the microenvironment of early and advanced pancreatic cancer to promote FAS-mediated killing by CD8+ T cells.
Mahadevan KK, McAndrews KM, LeBleu VS, Yang S, Lyu H, Li B, Sockwell AM, Kirtley ML, Morse SJ, Moreno Diaz BA, Kim MP, Feng N, Lopez AM, Guerrero PA, Paradiso F, Sugimoto H, Arian KA, Ying H, Barekatain Y, Sthanam LK, Kelly PJ, Maitra A, Heffernan TP, Kalluri R. Mahadevan KK, et al. Cancer Cell. 2023 Sep 11;41(9):1606-1620.e8. doi: 10.1016/j.ccell.2023.07.002. Epub 2023 Aug 24. Cancer Cell. 2023. PMID: 37625401
Uncloaking cell-impermeant gold nanorods via tumor microenvironmental cathepsin B facilitates cancer cell penetration and potent radiosensitization.
Raghuram S, Mackeyev Y, Symons J, Zahra Y, Gonzalez V, Mahadevan KK, Requejo KI, Liopo A, Derry P, Zubarev E, Sahin O, Byung-Kyu Kim J, Singh PK, Cho SH, Krishnan S. Raghuram S, et al. Among authors: mahadevan kk. Biomaterials. 2022 Dec;291:121887. doi: 10.1016/j.biomaterials.2022.121887. Epub 2022 Nov 2. Biomaterials. 2022. PMID: 36368139 Free PMC article.
Oncogenic collagen I homotrimers from cancer cells bind to α3β1 integrin and impact tumor microbiome and immunity to promote pancreatic cancer.
Chen Y, Yang S, Tavormina J, Tampe D, Zeisberg M, Wang H, Mahadevan KK, Wu CJ, Sugimoto H, Chang CC, Jenq RR, McAndrews KM, Kalluri R. Chen Y, et al. Among authors: mahadevan kk. Cancer Cell. 2022 Aug 8;40(8):818-834.e9. doi: 10.1016/j.ccell.2022.06.011. Epub 2022 Jul 21. Cancer Cell. 2022. PMID: 35868307 Free PMC article.
LGR5 in Barrett's Esophagus and its Utility in Predicting Patients at Increased Risk of Advanced Neoplasia.
Neyaz A, Odze RD, Rickelt S, Nieman LT, Bledsoe JR, Mahadevan KK, Arora K, Jeck WR, Taylor MS, Gala M, Patil DT, Yilmaz OH, Rivera MN, Ting DT, Deshpande V. Neyaz A, et al. Among authors: mahadevan kk. Clin Transl Gastroenterol. 2020 Dec 22;12(1):e00272. doi: 10.14309/ctg.0000000000000272. Clin Transl Gastroenterol. 2020. PMID: 33464729 Free PMC article.
19 results