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Page 1
Peripheral modulation of antidepressant targets MAO-B and GABAAR by harmol induces mitohormesis and delays aging in preclinical models.
Costa-Machado LF, Garcia-Dominguez E, McIntyre RL, Lopez-Aceituno JL, Ballesteros-Gonzalez Á, Tapia-Gonzalez A, Fabregat-Safont D, Eisenberg T, Gomez J, Plaza A, Sierra-Ramirez A, Perez M, Villanueva-Bermejo D, Fornari T, Loza MI, Herradon G, Hofer SJ, Magnes C, Madeo F, Duerr JS, Pozo OJ, Galindo MI, Del Pino I, Houtkooper RH, Megias D, Viña J, Gomez-Cabrera MC, Fernandez-Marcos PJ. Costa-Machado LF, et al. Among authors: magnes c. Nat Commun. 2023 May 15;14(1):2779. doi: 10.1038/s41467-023-38410-y. Nat Commun. 2023. PMID: 37188705 Free PMC article.
The flavonoid 4,4'-dimethoxychalcone promotes autophagy-dependent longevity across species.
Carmona-Gutierrez D, Zimmermann A, Kainz K, Pietrocola F, Chen G, Maglioni S, Schiavi A, Nah J, Mertel S, Beuschel CB, Castoldi F, Sica V, Trausinger G, Raml R, Sommer C, Schroeder S, Hofer SJ, Bauer MA, Pendl T, Tadic J, Dammbrueck C, Hu Z, Ruckenstuhl C, Eisenberg T, Durand S, Bossut N, Aprahamian F, Abdellatif M, Sedej S, Enot DP, Wolinski H, Dengjel J, Kepp O, Magnes C, Sinner F, Pieber TR, Sadoshima J, Ventura N, Sigrist SJ, Kroemer G, Madeo F. Carmona-Gutierrez D, et al. Among authors: magnes c. Nat Commun. 2019 Feb 19;10(1):651. doi: 10.1038/s41467-019-08555-w. Nat Commun. 2019. PMID: 30783116 Free PMC article.
Induction of autophagy by spermidine promotes longevity.
Eisenberg T, Knauer H, Schauer A, Büttner S, Ruckenstuhl C, Carmona-Gutierrez D, Ring J, Schroeder S, Magnes C, Antonacci L, Fussi H, Deszcz L, Hartl R, Schraml E, Criollo A, Megalou E, Weiskopf D, Laun P, Heeren G, Breitenbach M, Grubeck-Loebenstein B, Herker E, Fahrenkrog B, Fröhlich KU, Sinner F, Tavernarakis N, Minois N, Kroemer G, Madeo F. Eisenberg T, et al. Among authors: magnes c. Nat Cell Biol. 2009 Nov;11(11):1305-14. doi: 10.1038/ncb1975. Epub 2009 Oct 4. Nat Cell Biol. 2009. PMID: 19801973
Dietary spermidine improves cognitive function.
Schroeder S, Hofer SJ, Zimmermann A, Pechlaner R, Dammbrueck C, Pendl T, Marcello GM, Pogatschnigg V, Bergmann M, Müller M, Gschiel V, Ristic S, Tadic J, Iwata K, Richter G, Farzi A, Üçal M, Schäfer U, Poglitsch M, Royer P, Mekis R, Agreiter M, Tölle RC, Sótonyi P, Willeit J, Mairhofer B, Niederkofler H, Pallhuber I, Rungger G, Tilg H, Defrancesco M, Marksteiner J, Sinner F, Magnes C, Pieber TR, Holzer P, Kroemer G, Carmona-Gutierrez D, Scorrano L, Dengjel J, Madl T, Sedej S, Sigrist SJ, Rácz B, Kiechl S, Eisenberg T, Madeo F. Schroeder S, et al. Among authors: magnes c. Cell Rep. 2021 Apr 13;35(2):108985. doi: 10.1016/j.celrep.2021.108985. Cell Rep. 2021. PMID: 33852843 Free article.
Spermidine promotes mating and fertilization efficiency in model organisms.
Bauer MA, Carmona-Gutiérrez D, Ruckenstuhl C, Reisenbichler A, Megalou EV, Eisenberg T, Magnes C, Jungwirth H, Sinner FM, Pieber TR, Fröhlich KU, Kroemer G, Tavernarakis N, Madeo F. Bauer MA, et al. Among authors: magnes c. Cell Cycle. 2013 Jan 15;12(2):346-52. doi: 10.4161/cc.23199. Epub 2012 Jan 15. Cell Cycle. 2013. PMID: 23255134 Free PMC article.
Cardioprotection and lifespan extension by the natural polyamine spermidine.
Eisenberg T, Abdellatif M, Schroeder S, Primessnig U, Stekovic S, Pendl T, Harger A, Schipke J, Zimmermann A, Schmidt A, Tong M, Ruckenstuhl C, Dammbrueck C, Gross AS, Herbst V, Magnes C, Trausinger G, Narath S, Meinitzer A, Hu Z, Kirsch A, Eller K, Carmona-Gutierrez D, Büttner S, Pietrocola F, Knittelfelder O, Schrepfer E, Rockenfeller P, Simonini C, Rahn A, Horsch M, Moreth K, Beckers J, Fuchs H, Gailus-Durner V, Neff F, Janik D, Rathkolb B, Rozman J, de Angelis MH, Moustafa T, Haemmerle G, Mayr M, Willeit P, von Frieling-Salewsky M, Pieske B, Scorrano L, Pieber T, Pechlaner R, Willeit J, Sigrist SJ, Linke WA, Mühlfeld C, Sadoshima J, Dengjel J, Kiechl S, Kroemer G, Sedej S, Madeo F. Eisenberg T, et al. Among authors: magnes c. Nat Med. 2016 Dec;22(12):1428-1438. doi: 10.1038/nm.4222. Epub 2016 Nov 14. Nat Med. 2016. PMID: 27841876 Free PMC article.
Effects of Spermidine Supplementation on Cognition and Biomarkers in Older Adults With Subjective Cognitive Decline: A Randomized Clinical Trial.
Schwarz C, Benson GS, Horn N, Wurdack K, Grittner U, Schilling R, Märschenz S, Köbe T, Hofer SJ, Magnes C, Stekovic S, Eisenberg T, Sigrist SJ, Schmitz D, Wirth M, Madeo F, Flöel A. Schwarz C, et al. Among authors: magnes c. JAMA Netw Open. 2022 May 2;5(5):e2213875. doi: 10.1001/jamanetworkopen.2022.13875. JAMA Netw Open. 2022. PMID: 35616942 Free PMC article. Clinical Trial.
Spermidine supplementation and voluntary activity differentially affect obesity-related structural changes in the mouse lung.
Ahrendt N, Steingrüber T, Rajces A, Lopez-Rodriguez E, Eisenberg T, Magnes C, Madeo F, Sedej S, Schmiedl A, Ochs M, Mühlfeld C, Schipke J. Ahrendt N, et al. Among authors: magnes c. Am J Physiol Lung Cell Mol Physiol. 2020 Aug 1;319(2):L312-L324. doi: 10.1152/ajplung.00423.2019. Epub 2020 Jun 10. Am J Physiol Lung Cell Mol Physiol. 2020. PMID: 32521164 Free article.
Safety and tolerability of spermidine supplementation in mice and older adults with subjective cognitive decline.
Schwarz C, Stekovic S, Wirth M, Benson G, Royer P, Sigrist SJ, Pieber T, Dammbrueck C, Magnes C, Eisenberg T, Pendl T, Bohlken J, Köbe T, Madeo F, Flöel A. Schwarz C, et al. Among authors: magnes c. Aging (Albany NY). 2018 Jan 8;10(1):19-33. doi: 10.18632/aging.101354. Aging (Albany NY). 2018. PMID: 29315079 Free PMC article. Clinical Trial.
78 results