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Microtubule-targeting-compound PBOX-15 radiosensitizes cancer cells in vitro.
Forde JC, Maginn EN, McNamara G, Martin LM, Campiani G, Williams DC, Zisterer D, McElligott AM, Lawler M, Lynch TH, Hollywood D, Marignol L. Forde JC, et al. Among authors: maginn en. Cancer Biol Ther. 2011 Feb 15;11(4):421-8. doi: 10.4161/cbt.11.4.14183. Epub 2011 Feb 15. Cancer Biol Ther. 2011. PMID: 21131779
The novel tubulin-targeting agent pyrrolo-1,5-benzoxazepine-15 induces apoptosis in poor prognostic subgroups of chronic lymphocytic leukemia.
McElligott AM, Maginn EN, Greene LM, McGuckin S, Hayat A, Browne PV, Butini S, Campiani G, Catherwood MA, Vandenberghe E, Williams DC, Zisterer DM, Lawler M. McElligott AM, et al. Among authors: maginn en. Cancer Res. 2009 Nov 1;69(21):8366-75. doi: 10.1158/0008-5472.CAN-09-0131. Epub 2009 Oct 13. Cancer Res. 2009. PMID: 19826055 Free article.
PBOX-15, a novel microtubule targeting agent, induces apoptosis, upregulates death receptors, and potentiates TRAIL-mediated apoptosis in multiple myeloma cells.
Maginn EN, Browne PV, Hayden P, Vandenberghe E, MacDonagh B, Evans P, Goodyer M, Tewari P, Campiani G, Butini S, Williams DC, Zisterer DM, Lawler MP, McElligott AM. Maginn EN, et al. Br J Cancer. 2011 Jan 18;104(2):281-9. doi: 10.1038/sj.bjc.6606035. Epub 2010 Dec 21. Br J Cancer. 2011. PMID: 21179037 Free PMC article.