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Chloroquine attenuates diet-induced obesity and glucose intolerance through a mechanism that might involve FGF-21, but not UCP-1-mediated thermogenesis and inhibition of adipocyte autophagy.
Ortiz-Silva M, Leonardi BF, Castro É, Peixoto ÁS, Gilio GR, Oliveira TE, Tomazelli CA, Andrade ML, Moreno MF, Belchior T, Magdalon J, Vieira TS, Donado-Pestana CM, Festuccia WT. Ortiz-Silva M, et al. Among authors: magdalon j. Mol Cell Endocrinol. 2023 Dec 1;578:112074. doi: 10.1016/j.mce.2023.112074. Epub 2023 Sep 22. Mol Cell Endocrinol. 2023. PMID: 37742789
PPARγ activation attenuates glucose intolerance induced by mTOR inhibition with rapamycin in rats.
Festuccia WT, Blanchard PG, Belchior T, Chimin P, Paschoal VA, Magdalon J, Hirabara SM, Simões D, St-Pierre P, Carpinelli A, Marette A, Deshaies Y. Festuccia WT, et al. Among authors: magdalon j. Am J Physiol Endocrinol Metab. 2014 May 1;306(9):E1046-54. doi: 10.1152/ajpendo.00683.2013. Epub 2014 Mar 11. Am J Physiol Endocrinol Metab. 2014. PMID: 24619883 Free article.
mTORC1 inhibition with rapamycin exacerbates adipose tissue inflammation in obese mice and dissociates macrophage phenotype from function.
Paschoal VA, Amano MT, Belchior T, Magdalon J, Chimin P, Andrade ML, Ortiz-Silva M, Castro É, Yamashita AS, Rosa Neto JC, Câmara NO, Festuccia WT. Paschoal VA, et al. Among authors: magdalon j. Immunobiology. 2017 Feb;222(2):261-271. doi: 10.1016/j.imbio.2016.09.014. Epub 2016 Sep 28. Immunobiology. 2017. PMID: 27692982
Regulation of adiposity by mTORC1.
Magdalon J, Festuccia WT. Magdalon J, et al. Einstein (Sao Paulo). 2017 Oct-Dec;15(4):507-511. doi: 10.1590/S1679-45082017RB4106. Einstein (Sao Paulo). 2017. PMID: 29364369 Free PMC article. Review.
Constitutive Activation of the Nutrient Sensor mTORC1 in Myeloid Cells Induced by Tsc1 Deletion Protects Mice from Diet-Induced Obesity.
Paschoal VA, Belchior T, Amano MT, Burgos-Silva M, Peixoto AS, Magdalon J, Vieira TS, Andrade ML, Moreno MF, Chimin P, Câmara NO, Festuccia WT. Paschoal VA, et al. Among authors: magdalon j. Mol Nutr Food Res. 2018 Sep;62(17):e1800283. doi: 10.1002/mnfr.201800283. Epub 2018 Aug 8. Mol Nutr Food Res. 2018. PMID: 30001482
PPARγ-induced upregulation of subcutaneous fat adiponectin secretion, glyceroneogenesis and BCAA oxidation requires mTORC1 activity.
Andrade ML, Gilio GR, Perandini LA, Peixoto AS, Moreno MF, Castro É, Oliveira TE, Vieira TS, Ortiz-Silva M, Thomazelli CA, Chaves-Filho AB, Belchior T, Chimin P, Magdalon J, Ivison R, Pant D, Tsai L, Yoshinaga MY, Miyamoto S, Festuccia WT. Andrade ML, et al. Among authors: magdalon j. Biochim Biophys Acta Mol Cell Biol Lipids. 2021 Aug;1866(8):158967. doi: 10.1016/j.bbalip.2021.158967. Epub 2021 May 15. Biochim Biophys Acta Mol Cell Biol Lipids. 2021. PMID: 34004356 Free PMC article.
Omega-3 fatty acids protect from diet-induced obesity, glucose intolerance, and adipose tissue inflammation through PPARγ-dependent and PPARγ-independent actions.
Belchior T, Paschoal VA, Magdalon J, Chimin P, Farias TM, Chaves-Filho AB, Gorjão R, St-Pierre P, Miyamoto S, Kang JX, Deshaies Y, Marette A, Festuccia W. Belchior T, et al. Among authors: magdalon j. Mol Nutr Food Res. 2015 May;59(5):957-67. doi: 10.1002/mnfr.201400914. Epub 2015 Mar 16. Mol Nutr Food Res. 2015. PMID: 25641959
Adipocyte mTORC1 deficiency promotes adipose tissue inflammation and NLRP3 inflammasome activation via oxidative stress and de novo ceramide synthesis.
Chimin P, Andrade ML, Belchior T, Paschoal VA, Magdalon J, Yamashita AS, Castro É, Castoldi A, Chaves-Filho AB, Yoshinaga MY, Miyamoto S, Câmara NO, Festuccia WT. Chimin P, et al. Among authors: magdalon j. J Lipid Res. 2017 Sep;58(9):1797-1807. doi: 10.1194/jlr.M074518. Epub 2017 Jul 5. J Lipid Res. 2017. PMID: 28679588 Free PMC article.
24 results