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Year Number of Results
2004 1
2008 1
2011 5
2012 3
2013 4
2014 5
2015 8
2016 7
2017 7
2018 10
2019 8
2020 7
2021 4
2022 7
2023 8
2024 1

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73 results

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Page 1
First-in-Class Selenium-Containing Potent Serotonin Receptor 5-HT6 Agents with a Beneficial Neuroprotective Profile against Alzheimer's Disease.
Pyka P, Haberek W, Więcek M, Szymanska E, Ali W, Cios A, Jastrzębska-Więsek M, Satała G, Podlewska S, Di Giacomo S, Di Sotto A, Garbo S, Karcz T, Lambona C, Marocco F, Latacz G, Sudoł-Tałaj S, Mordyl B, Głuch-Lutwin M, Siwek A, Czarnota-Łydka K, Gogola D, Olejarz-Maciej A, Wilczyńska-Zawal N, Honkisz-Orzechowska E, Starek M, Dąbrowska M, Kucwaj-Brysz K, Fioravanti R, Nasim MJ, Hittinger M, Partyka A, Wesołowska A, Battistelli C, Zwergel C, Handzlik J. Pyka P, et al. Among authors: jastrzebska wiesek m. J Med Chem. 2024 Jan 25;67(2):1580-1610. doi: 10.1021/acs.jmedchem.3c02148. Epub 2024 Jan 8. J Med Chem. 2024. PMID: 38190615 Free PMC article.
The Subtype Selectivity in Search of Potent Hypotensive Agents among 5,5-Dimethylhydantoin Derived α1-Adrenoceptors Antagonists.
Kaczor A, Knutelska J, Kucwaj-Brysz K, Zygmunt M, Żesławska E, Siwek A, Bednarski M, Podlewska S, Jastrzębska-Więsek M, Nitek W, Sapa J, Handzlik J. Kaczor A, et al. Among authors: jastrzebska wiesek m. Int J Mol Sci. 2023 Nov 22;24(23):16609. doi: 10.3390/ijms242316609. Int J Mol Sci. 2023. PMID: 38068933 Free PMC article.
Anti-Inflammatory Activities of 8-Benzylaminoxanthines Showing High Adenosine A2A and Dual A1/A2A Receptor Affinity.
Załuski M, Łażewska D, Jaśko P, Honkisz-Orzechowska E, Kuder KJ, Brockmann A, Latacz G, Zygmunt M, Kaleta M, Greser BA, Olejarz-Maciej A, Jastrzębska-Więsek M, Vielmuth C, Müller CE, Kieć-Kononowicz K. Załuski M, et al. Among authors: jastrzebska wiesek m. Int J Mol Sci. 2023 Sep 5;24(18):13707. doi: 10.3390/ijms241813707. Int J Mol Sci. 2023. PMID: 37762006 Free PMC article.
Hydrophobicity modulation via the substituents at positions 2 and 4 of 1,3,5-triazine to enhance therapeutic ability against Alzheimer's disease for potent serotonin 5-HT6R agents.
Sudoł-Tałaj S, Kucwaj-Brysz K, Podlewska S, Kurczab R, Satała G, Mordyl B, Głuch-Lutwin M, Wilczyńska-Zawal N, Jastrzębska-Więsek M, Czarnota-Łydka K, Kurowska K, Kubacka M, Żesławska E, Nitek W, Olejarz-Maciej A, Doroz-Płonka A, Partyka A, Latacz G, Wesołowska A, Handzlik J. Sudoł-Tałaj S, et al. Among authors: jastrzebska wiesek m. Eur J Med Chem. 2023 Nov 15;260:115756. doi: 10.1016/j.ejmech.2023.115756. Epub 2023 Aug 24. Eur J Med Chem. 2023. PMID: 37657272 Free article.
Synthesis, computational and experimental pharmacological studies for (thio)ether-triazine 5-HT6R ligands with noticeable action on AChE/BChE and chalcogen-dependent intrinsic activity in search for new class of drugs against Alzheimer's disease.
Czarnota-Łydka K, Sudoł-Tałaj S, Kucwaj-Brysz K, Kurczab R, Satała G, de Candia M, Samarelli F, Altomare CD, Carocci A, Barbarossa A, Żesławska E, Głuch-Lutwin M, Mordyl B, Kubacka M, Wilczyńska-Zawal N, Jastrzębska-Więsek M, Partyka A, Khan N, Więcek M, Nitek W, Honkisz-Orzechowska E, Latacz G, Wesołowska A, Carrieri A, Handzlik J. Czarnota-Łydka K, et al. Among authors: jastrzebska wiesek m. Eur J Med Chem. 2023 Nov 5;259:115695. doi: 10.1016/j.ejmech.2023.115695. Epub 2023 Jul 30. Eur J Med Chem. 2023. PMID: 37567058 Free article.
Synthesis, computational simulations and biological evaluation of new dual 5HT1A/5HT7 receptor ligands based on purine-2,6-dione scaffold.
Zagórska A, Partyka A, Jastrzębska-Więsek M, Czopek A, Fryc M, Siwek A, Głuch-Lutwin M, Mordyl B, Maślanka A, Jaromin A, Kurczab R. Zagórska A, et al. Among authors: jastrzebska wiesek m. Bioorg Chem. 2023 Oct;139:106737. doi: 10.1016/j.bioorg.2023.106737. Epub 2023 Jul 19. Bioorg Chem. 2023. PMID: 37482048 Free article.
Hybrid molecules combining GABA-A and serotonin 5-HT6 receptors activity designed to tackle neuroinflammation associated with depression.
Marcinkowska M, Mordyl B, Fajkis-Zajaczkowska N, Siwek A, Karcz T, Gawalska A, Bucki A, Żmudzki P, Partyka A, Jastrzębska-Więsek M, Pomierny B, Walczak M, Smolik M, Pytka K, Mika K, Kotańska M, Kolaczkowski M. Marcinkowska M, et al. Among authors: jastrzebska wiesek m. Eur J Med Chem. 2023 Feb 5;247:115071. doi: 10.1016/j.ejmech.2022.115071. Epub 2022 Dec 29. Eur J Med Chem. 2023. PMID: 36603509
HBK-15, a Multimodal Compound, Showed an Anxiolytic-Like Effect in Rats.
Lustyk K, Sałaciak K, Jakubczyk M, Jastrzębska-Więsek M, Partyka A, Wesołowska A, Marona H, Pytka K. Lustyk K, et al. Among authors: jastrzebska wiesek m. Neurochem Res. 2023 Mar;48(3):839-845. doi: 10.1007/s11064-022-03802-x. Epub 2022 Nov 9. Neurochem Res. 2023. PMID: 36350432 Free PMC article.
The Antidepressant-like Activity, Effects on Recognition Memory Deficits, Bioavailability, and Safety after Chronic Administration of New Dual-Acting Small Compounds Targeting Neuropsychiatric Symptoms in Dementia.
Jastrzębska-Więsek M, Kotańska M, Grzeszczak A, Jaromin A, Walczak M, Partyka A, Gdula-Argasińska J, Smolik M, Zagórska A. Jastrzębska-Więsek M, et al. Int J Mol Sci. 2022 Sep 28;23(19):11452. doi: 10.3390/ijms231911452. Int J Mol Sci. 2022. PMID: 36232749 Free PMC article.
73 results